BACKGROUND Sunitinib is a multi-targeted tyrosine kinase inhibitor used in the treatment of advanced renal cell carcinoma (RCC) and imatinib-resistant/intolerant gastrointestinal stromal tumors (GIST). METHODS A meta-analysis of 10 prospective clinical studies in advanced RCC and GIST was performed to support the development of pharmacokinetic (PK) and PK/pharmacodynamic (PD) models that acco...

We assessed whether educational inequalities in mental health may be mediated by employment status and household income. Poor mental health was assessed using General Health Questionnaire 'caseness' in working age adult participants (N = 48 654) of the Health Survey for England (2001-10). Relative indices of inequality by education level were calculated. Substantial inequalities were apparent, ...

Background: The prevalence of cognitive disorders among older individuals is considered to be one of the most significant and controversial health problems. This study was conducted with the aim of determining the effect of Superbrain yoga exercises on the older adult’s cognitive status. This study was conducted with the aim of determining the effect of Superbrain yoga exercises on the older ad...

We compared two methods for programming and thinning noncontingent reinforcement (NCR) schedules during the treatment of self-injurious behavior (SIB). The participants were 3 individuals who had been diagnosed with mental retardation. Results of functional analyses indicated that all participants' SIB was maintained by positive reinforcement (i.e., access to attention or food). Following basel...

background and aim: the most important component of each organization is its workforce. improving employees’ mental health and commitment is the prerequisites to training a healthy workforce. this study was undertaken to examine the relationship of organizational commitment (oc) with mental health among employees of birjand university of medical sciences, birjand, iran. methods: in this correla...

results the prevalence of excessive mobile phone use was 36.7% on the students. there was a significant relation between the prevalence of excessive mobile phone use and mental health status in general (p > 0.05), and also somatization (p < 0.05), anxiety and depression specifically (p < 0.05), but no significant relation was found between the excessive mobile phone use and social dysfunction (...

conclusions this study showed that 36% of the patients with mild tbi symptoms had mental health problems. given the high rates of psychologic disorders among patients with mild tbi, it is necessary to reduce the factors that caused the disorder. results a total of 286 patients, 79.7% males and 20.3% females with male to female ratio of 4:1, completed the study. female had significantly higher g...

We introduce grading into games of status. Each player chooses effort, producing a stochastic output or score. Utilities depend on the ranking of all the scores. By clustering scores into grades, the ranking is coarsened, and the incentives to work are changed. We first apply games of status to grading exams. Our main conclusion is that if students care primarily about their status (relative ra...