There has been speculation that the addition of menthol to cigarettes may affect the manner in which cigarettes are smoked, potentially influencing smokers' exposures to smoke constituents that have been associated with smoking-related diseases. One hundred twelve male and female smokers participated in a parallel-arm study to determine whether the ad libitum smoking of menthol cigarettes resul...

Stimulation of Ca2+ absorption can counteract hypocalcemia at the onset lactation. The plant bioactive lipid compound (PBLC) menthol is an agonist for nonselective cation channels transient receptor potential (TRP) family. It acutely stimulated in ruminal epithelia nonadapted animals ex vivo and caused higher plasma concentrations cows sheep vivo. To elucidate pathway by which feeding increases...

Severe allergic reactions to cologne or perfumes are rarely reported. Perfumes or colognes may aggravate respiratory symptoms in patients with asthma and they are also targeted as one of the most common causes of cosmetic allergic contact dermatitis.1,2 However, there is only one case of anaphylaxis to perfume reported in the literature.2 We report the case of an infant who developed anaphylaxi...

YAMAMURA AND COLLEAGUES (17) report that melanoma cells express transient receptor potential melastatin subfamily member 8 (TRPM8) receptors and that their activation suppresses melanoma viability. This effect is mediated by menthol, and the mechanism of action involves the influx of extracellular Ca . This finding opens new and exciting possibilities in melanoma research, to wit, that natural ...

(-)-Menthone is the predominant monoterpene produced in the essential oil of maturing peppermint (Mentha x piperita) leaves during the filling of epidermal oil glands. This early biosynthetic process is followed by a second, later oil maturation program (approximately coincident with flower initiation) in which the C3-carbonyl of menthone is reduced to yield (-)-(3R)-menthol and (+)-(3S)-neomen...

BACKGROUND The cooling agents menthol and icilin act as agonists at TRPM8 and TRPA1. In vitro, activation of TRPM8 by icilin and cold, but not menthol, is dependent on the activity of a sub-type of phospholipase A2, iPLA2. Lysophospholipids (e.g. LPC) produced by PLA2 activity can also activate TRPM8. The role of TRPA1 as a primary cold sensor in vitro is controversial, although there is eviden...

Topical capsaicin is reported to be an effective treatment for idiopathic intractable pruritus ani. While both capsaicin and menthol application produce a transient perianal burning sensation, only capsaicin relieves itching. Classical observations on functional desensitisation of nociceptors by capsaicin may explain the beneficial effects but the recent discovery of a range of receptors which ...

The solid–liquid equilibrium (SLE) behavior and liquid–liquid extraction (LLX) abilities of deep eutectic solvents (DESs) containing (a) thymol L-menthol, (b) trioctylphosphine oxide (TOPO) L-menthol were evaluated. distribution coefficients (KD) determined for the solutes relevant two biorefinery cases, including formic acid, levulinic furfural, acetic propionic butyric L-lactic acid. Overall,...