Mer receptor tyrosine kinase (Mer) signaling plays a central role in the intrinsic inhibition of the inflammatory response to Tolllike receptor activation. Previously, we found that lung Mer protein expression decreased after lipopolysaccharide (LPS) treatment due to enhanced Mer cleavage. The purpose of the present study was to examine whether pharmacologically restored membrane-bound Mer expr...

Five human tumor cell lines of the Mer- phenotype sensitive to killing by the methylating agent 5-(3-methyl-1-triazeno)imidazole-4-carboxamide were sensitive to hydroxyurea (HU) compared with 15 cell lines resistant to methylating agents (Mer+ phenotype). In a study using fewer cell lines, Mer- cells were also sensitive to methotrexate but not to seven other agents including the antimetabolites...

The recently proposed statistical temperature molecular dynamics (STMD) algorithm [Kim, Phys. Rev. Lett. 97, 050601 (2006)] is used as the core of an optimization algorithm, statistical temperature annealing (STA), for finding low-lying energy minima of complex potential energy landscapes. Since STMD realizes a random walk in energy, the idea is simply to initiate repeated minimizations from co...

Transcription factors are short stretches of DNA (or k-mers) mainly located in promoters sequences that enhance or repress gene expression. With respect to an initial distribution of letters on the DNA alphabet, Behrens and Vingron [3] consider a random sequence of length n that does not contain a given k-mer or word of size k. Under an evolution model of the DNA, they compute the probability p...

INTRODUCTION The requirement for the immunoregulatory Mer tyrosine kinase (Mer) for optimal removal of apoptotic cells prompted us to look at its expression in systemic lupus erythematosus (SLE), in which apoptotic cell clearance is abnormal. We compared the levels of expression of Mer in normal human subjects and in patients with SLE. METHODS We used flow cytometry of isolated peripheral blo...

The purpose of the study was to identify the relationships between segmental angular momentum and ball velocity between the following events: ball toss, maximal elbow flexion (MEF), racket lowest point (RLP), maximal shoulder external rotation (MER), and ball impact (BI). Ten tennis players performed serves recorded with a real-time motion capture. Mean angular momentums of the trunk, upper arm...

Abstrakt Denna artikel utvärderar en strukturerad metod för registrering av brottsplatsuppgifter från mängd/vardagsbrott genom en jämförelse med traditionella textbaserade brottsanmälningar. En initial användarstudie kopplat till ett bostadsinbrott utvärderar effektiviteten hos de båda metoderna. Effektiviteten kvantifieras som dels tiden det tar att registrera bostadsinbrottet samt antalet rel...