We report the case of an octagenerian who presented with leukocytoclastic vasculitis as the first symptom of Crohn’s disease. The patient was admitted with skin rash on the lower extremities and ankles and episodes of bloody diarrhea. Skin and colon biopsies revealed acute leukocytoclastic vasculitis and moderate Crohn’s disease, respectively. The patient was treated with intravenous corticoste...

Nephrotoxicity in association with 5-aminosalicylic acid therapy is well recognised. In this patient the nephrotoxicity only became apparent after severe weight loss had occurred in association with nephrogenic diabetes insipidus. The patient aged 26 with ulcerative colitis received resin coated mesalazine (Asacol) 1200 mg/day and lost 12 kg in weight over a four month period, only complaining ...

(mesalazine), used for both induction and maintenance of remission therapy, in epidemiological retrospective studies. There is also supportive experimental evidence that 5-ASA agents increase apoptosis, decrease proliferation and inhibit the formation of aberrant crypt foci, as well as reducing the spontaneous mutation rate at a (CA) 13 microsatellite, a mutation linked with chronic inflammatio...

Severe diarrhoea in patients with the acquired immune deficiency syndrome (AIDS) is usually a manifestation of gastrointestinal infection by a variety of organisms. We report a patient with low CD4 T cell counts who developed ulcerative colitis after amoebic dysentery. He subsequently developed acute ulcerative colitis with toxic dilatation while he was severely immunocompromised. He responded ...