BACKGROUND AND OBJECTIVES Human mesenchymal stem/progenitor cells (MSPC) ar pluripotent, being the precursors for marrow stroma, bone, cartilage, muscle and connective tissues. Although the presence of hematopoietic stem/progenitor cells (HSPC) in umbilical cord blood (UCB) is well known, that of MSPC has been not fully evaluated. DESIGN AND METHODS In this study, we examined the immunophenot...

Recently various kinds of cardiac stem/progenitor cells have been identified and suggested to be involved in cardiac repair and regeneration in injured myocardium. In this review, we focus on the roles of JAK-STAT signaling in cardiac stem/progenitor cells in cardiomyogenesis. JAK-STAT signaling plays important roles in the differentiation of stem cells into cardiac lineage cells. The activatio...

BACKGROUND Bone marrow stromal cells (BMSCs) have many characteristics of mesenchymal stem cells that can differentiate into smooth muscle cells (SMCs). However, there have been few studies closely following the cell development of smooth muscle lineage among BMSCs. METHODS AND RESULTS To investigate the possible existence of a cell population committed to the SMC lineage among bone marrow ad...

statement of the problem: recently allogenic mesenchymal stem cells are proposed to have multipotential progenitor cell capabilities to differentiate into cementoblasts, osteoblasts, and periodontal ligament fibroblasts. purpose: the aim of the present study was to compare the efficacy of human umbilical stem cells cultured on polylactic acid (pla), polyglycolic acid (pga) membrane with pla/pga...

Long-standing diabetes leads to structural and functional alterations in both the micro- and the macrovasculature. Designing therapies to repair these abnormalities present unique and sophisticated challenges. Vascular endothelial cells are the primary cells damaged by hyperglycemia-induced adverse effects. Vascular stem cells that give rise to endothelial progenitor cells and mesenchymal proge...

BACKGROUND Progenitor cell therapy is emerging as a novel treatment for heart failure. However the molecular mechanisms regulating the generation of cardiac progenitor cells is not fully understood. We hypothesized that cardiac progenitor cells are generated from cardiac explant via a process similar to epithelial to mesenchymal transition (EMT). METHODS/FINDINGS Explant-derived cells were ge...

conclusions the results of this study showed that the meticulous microsurgical nerve repair, which was performed using the vein tubulization induced significantly better sciatic nerve regeneration. however, the addition of bone marrow mesenchymal stem cell to vein conduit failed to promote any significant changes in regeneration outcome. results all animals tolerated the surgical procedures and...

objective(s): in this study, the effect of electrospun fiber orientation on proliferation and differentiation of mesenchymal stem cells (mscs) was evaluated. materials and methods: aligned and random nanocomposite nanofibrous scaffolds were electrospun from polylactic acid (pla), poly (vinyl alcohol) (pva) and calcium carbonate nanoparticles (ncap). the surface morphology of prepared nanofibrou...

background: recently, stem cells have been considered for the treatment of heart diseases, but no marked improvement has been recorded. this is the first study to examine the functional and histological effects of the transplantation of human amniotic mesenchymal stromal cells (hamscs) in rats with heart failure (hf). methods: this study was conducted in the years 2014 and 2015. 35 male wistar ...