Sarcomatoid carcinoma is a type of spindle cell neoplasm. These varieties neoplasms comprise diverse collection benign and malignant neoplasms. carcinoma, also known by various other names such as Spindle Lane’s tumor, to name few, an exceedingly rare aggressive variant squamous 3, 7, 8 The variation in its nomenclature reflects the divergent interpretation sarcomatoid component reactive or neo...

The last decade has witnessed a substantial expansion in the field of microRNA (miRNA) biology, providing crucial insights into role miRNAs disease pathology, predominantly cancer progression and its metastatic spread. discovery tumor-suppressing represents potential approach for developing novel therapeutics. In this context, through miRNA microarray analysis, we examined consequences Prostate...

UNLABELLED Intratumoral heterogeneity correlates with clinical outcome and reflects the cellular complexity and dynamics within a tumor. Such heterogeneity is thought to contribute to radio- and chemoresistance because many treatments may target only certain tumor cell subpopulations. A better understanding of the functional interactions between various subpopulations of cells, therefore, may h...

Osteosarcoma is a malignant tumor with mesenchymal origin, most commonly found in extremities, pelvis and axial skeleton, including only 6% mandibular maxillary involvement. In jaws, this lesion is, generally, single predilection for posterior ramus mandible men the third or fouth decade of life. The aim study report 57year old woman diagnosed osteosarcoma region treated surgical resection asso...

A 66-year-old man was referred for evaluation and management of persistent hypophosphatemia (0.42 mmol/l) related to hyperphosphaturia. The patient reported intense diffuse osteoarticular pain since 1 year with weight loss 9 kg. Osteomalacia diagnosed a Fanconi syndrome ruled out. An increased plasma value fibroblast growth factor 23 observed (2.5-fold the upper range limit), suggesting presenc...

Gastrointestinal stromal tumor (GIST) is a rare form of mesenchymal tumor of the gastrointestinal tract, accounting for 1% of malignant neoplasms [1]. Most gastrointestinal mesenchymal tumors are GISTs, originating from interstitial cells of Cajal or precursors of these cells. Although several reports regarding GIST have incrementally advanced our understanding of this condition in recent years...

Glioblastoma (GBM) is the most common brain tumor in adults and the mesenchymal GBM subtype was reported to be the most malignant, presenting severe hypoxia and necrosis. Here, we investigated the possible role of a hypoxic microenvironment for inducing a mesenchymal and invasive phenotype. The exposure of non-mesenchymal SNB75 and U87 cells to hypoxia induced a strong change in cell morphology...

Epithelial plasticity involved the terminal and transitional stages that occur during epithelial-to-mesenchymal transition (EMT) mesenchymal-to-epithelial (MET), both are essential at different of early embryonic development have been co-opted by cancer cells to undergo tumor metastasis. These processes regulated multiple instances, whereas post-transcriptional regulation key genes mediated mic...

Unraveling the genetic programs that drive -metastasis may offer insights into how to limit or prevent this deadly aspect of cancer progression. Our recent studies indicate that tumor cell metastasis involves the activity of the transcription factor, Twist, which regulates epithelial-mesenchymal transition and early embryonic morphogenesis. Here, we review the Twist signaling pathway during nor...

Tumor cells exhibit two interconvertible modes of cell motility referred to as mesenchymal and amoeboid migration. Mesenchymal mode is characterized by elongated morphology that requires high GTPase Rac activation, whereas amoeboid mode is dependent on actomyosin contractility induced by Rho/Rho-associated protein kinase (ROCK) signaling. While elongated morphology is driven by Rac-induced prot...