Background: Rapid repair of skin donor sites in partial-thickness skin grafts in burn is critical to the patient. Severe pain during dressing change and scarring also reduce the quality of life and treatment. Recently, nano-silver particles are available which have a high surface to volume ratio and remain effective even at a very low concentration and minimize the chance for tissue toxicity du...

Background: Active Leptospermum honey has non-peroxide antibacterial and anti-inflammatory effects, rendering it suitable for wound healing. Leptospermum honey is endemic in New Zealand belonging to the manuka bush (Leptospermum scoparium). The objective of the present research was to compare the efficacy of manuka honey dressing with conventional dressing regarding skin graft donor sites...

Background: The surgical treatment of large and giant congenital melanocytic nevus (CMN) presents a great challenge. There is no consensus regarding the optimal surgical management. The purpose of this study was to assess the clinical effect of full-thickness skin grafts to repair defects after removal of the large and giant CMN on the face and joints region. Methods: Between March 2012 and Jul...

BACKGROUND In cases of early stage subungual melanoma (SUM), conservative treatment with non-amputative wide excision of the nail unit and subsequent skin graft is preferred over amputation to preserve the involved digit. OBJECTIVE We report a series of patients with SUM treated with conservative surgery and suggest an effective supplementary treatment process. METHODS We retrospectively re...

OBJECTIVE To examine the effectiveness of topical phenytoin in preserving the skin viability and increasing acceptance rate of autograft. METHODS We conducted this study in the Central Laboratory Animal House of Jordan University of Science and Technology, Irbid, Jordan during the period from September 2004 to June 2005. Forty-two rats were divided into 2 equal groups; full thickness dorsal s...

To date, transplant arteriosclerosis (TA), the histologic counterpart of chronic transplant dysfunction, is the most important problem in clinical organ transplantation. Recently we showed in rats that intrathymic (IT) immune modulation substantially prolonged graft survival of MHC-incompatible, heterotopic vascularized cardiac allografts. Although acute rejection was prevented, eventually TA w...

BACKGROUND Dystrophic skin scarring commonly occurs following skin cancer resections. In particular, the cosmetic outcome of skin graft reconstructions, following epidermoidal carcinoma removal, is generally poor due to wide marginal tumour excision, loss of subcutaneous tissues, and subsequent pigmented atrophic scarring of the graft coverage. Skin grafting sequelae need a three dimensional co...

We have investigated which T cell subclass defined by cytolysis with monoclonal anti-Lyt-1.2 and anti-Lyt-2.2 antibodies is required to adoptively transfer the ability to reject skin grafts. B6.Thy-1.1 spleen cells immune to graft antigens were fractionated with antibody plus C' and transferred to adult thymectomized, irradiated, bone marrow-reconstituted (ATXBM) B6.Thy-1.2 hosts that were simu...

BACKGROUND Successful skin grafting requires multiple factors for success. An even distribution of constant pressure exerted upon the graft is necessary for successful graft take. It is well known that excessive pressure on a graft causes ischemia and may result in the failure of graft take. The aim of this study was to demonstrate the variation in skin pressure (tension) on curved surfaces, pa...