BACKGROUND As an increasingly large number of meta-analyses are published, quantitative methods are needed to help clinicians and systematic review teams determine when meta-analyses are not up to date. METHODS We propose new methods for determining when non-significant meta-analytic results might be overturned, based on a prediction of the number of participants required in new studies. To g...

We evaluated the most common indices to compare their sensitivity and specificity to introduce the most sensitive and specific index. We systematically searched five international indexing databases up to Dec 2018. For each index, we measured the diagnostic odds ratio (DOR), as well as summary ROC (SROC) curve which was used to compare the performance of each index. Deeks̕ tests of all discrimin...

BACKGROUND The purpose of this meta-analysis was to evaluate the diagnostic accuracy of perfusion magnetic resonance imaging (MRI) as a method for differentiating glioma recurrence from pseudoprogression. METHODS The PubMed, Embase, Cochrane Library, and Chinese Biomedical databases were searched comprehensively for relevant studies up to August 3, 2016 according to specific inclusion and exc...

METANET4U is a European project aiming at supporting language technology for European languages and multilingualism. It is a project in the META-NET Network of Excellence, a cluster of projects aiming at fostering the mission of META, which is the Multilingual Europe Technology Alliance, dedicated to building the technological foundations of a multilingual European information society. This pap...

This chapter introduces a multi-level, multidimensional meta-framework for successful implementations of EHR in healthcare organizations. Existing implementation frameworks do not explain many features experienced and reported by implementers and have not helped to make health information technology implementation any more successful. To close this gap, we have developed an EHR implementation f...

Information technology has had a significant impact on business operations and allowed the emergence of new business models. These IT-enabled processes and businesses however depend on secure information systems which need to be managed. The management of information systems security (ISS) is a highly dynamic and complex task due to constant change in the information technology domain. In this ...

Enabling technology for realizing ad-hoc business processes currently is becoming more and more popular, like for example web services. Ad-hoc business processes are semantically characterized by a description of the exchanged messages and by the potential message sequences. These semantic meta-data are required to enable efficient and precise searching and finding of potential trading partners...

Theoretical compensation after anterior cruciate ligament (ACL) tear could cause quadriceps weakness and hamstring activation, preventing anterior tibial subluxation and affecting the expected hamstring-to-quadriceps ratio. Although quadriceps weakness often occurs after ACL tears, it remains unclear whether hamstring strength and hamstring-to-quadriceps ratio increase in ACL deficient knees. T...

BACKGROUND Diagnosis of mandibular involvement caused by head and neck cancers is critical for treatment. We performed a meta-analysis to determine the diagnostic efficacy of MR for distinguishing mandibular involvement caused by head and neck cancers. METHODS Thirteen databases were searched electronically and hand-searching was also done. Two reviewers conducted study inclusion, data extrac...

background: several epidemiological studies suggest that tobacco smoking increases the risk of oral cancer. no systematic review, however, has been reported to examine how consistent the evidence is across the studies. we undertook a meta-analysis of epidemiological studies investigating the magnitude relationship between tobacco smoking and oral cancer. methods: primary studies were identified...