background: thalassemia is the most common hereditary anemia and beta thalassemia major is its most severe form. endocrine abnormalities in thalassemia major are common disturbing complications that need prompt management. the purpose of this study was to determine the endocrine disorders and bone mineral density in patients with major -thalassemia in qazvin, iran. methods: in this cross- secti...

in 1902, well known archibald garrod applied mendels gene concept to human characters. he opened a new window in understanding the etiology of metabolic disorders. he proposed biochemical changes as the etiology of metabolic disorders in his series of papers inborn errors of metabolism (1906). after establishing prenatal diagnosis facilities for the detection of chromosomal abnormalities in our...