Obesity is a major risk factor for both obstructive sleep apnoea (OSA) and metabolic disease. As obesity rates continue to rise, so too does the prevalence of OSA and metabolic disorders. Indeed, recent community sample data from over 2000 adults aged 40–85 years in Switzerland indicate that up to 50% of men and almost a quarter of women have apnoea–hypopnoea indices (AHI) within the moderate t...

This study aimed to investigate whether the predictive values of intensity- and volume-based PET parameters are different between histological subtypes in patients with cervical cancer. Ninety patients, 65 with squamous cell carcinoma (SCC) and 25 with non-SCC (NSCC), who underwent pretreatment ¹⁸F-FDG PET/CT and pelvic MRI, were studied retrospectively. In addition to SUVmax and SUVmean, metab...

OBJECTIVE To investigate the effects of vitamin D deficiency on both insulin resistance and risk of metabolic syndrome in children. METHODS The study group consisted of 301 children and adolescents with a mean age of 14.2 ± 1.8 years. Serum 25-hydroxyvitamin D [25(OH)D] levels and insulin resistance indices were evaluated. According to serum 25(OH)D levels, the subjects were classified in 3 g...

PURPOSE Reduced heart rate variability significantly increases cardiovascular mortality. Metabolic syndrome increases the cardiac autonomic dysfunction. Recently, increasing cardiovascular mortality has been reported in patients with schizophrenia. This study was done to compare heart rate variability between adults with and without schizophrenia and to compare the relationship of heart rate va...

Fifteen compounds reported to be inhibitors of gelation or sickling were studied by standard methods. These tests included (1) the determination of the solubility of deoxyhemoglobin S or Csat, (2) evaluation of sickling in whole SS blood at various pO2s, (3) measurement of the oxygen affinity of hemoglobin and blood, and (4) examination of red cell indices and morphology. Among the 4 noncovalen...

Abstract Background Gestational diabetes mellitus (GDM), one of the most common pregnancy complications, can lead to morbidity and mortality in both mother infant. Metabolomics has provided new insights into pathology GDM systemic analysis with metabolites is required for providing more clues diagnosis mechanism research. This study aims reveal metabolic differences between normal pregnant wome...

Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the conversion of stearate (18:0) to oleate (18:1n-9) and of palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty acid metabolic network. This study investigated the role of SCD1 in fatty acid metabolism in HepG2 cells using SCD1 inhibitors and stable isotope tracers. HepG2 cells were cultured with ...

The features of the vasoregulating function vascular endothelium have been determined and correlations between haemodynamic metabolic indices established in patients with coronary heart disease associated type II diabetes mellitus. In mellitus comparison without an association significantly higher content blood fibrinogen diameter brachial artery (after decompression) were observed. Direct fast...