نتایج جستجو برای: metabolic inhibitors
تعداد نتایج: 400066 فیلتر نتایج به سال:
The arachidonic acid (AA) metabolic network produces key inflammatory mediators which have been considered as hallmark contributors in various inflammatory related diseases. Enzymes in this network, such as 5-lipoxygenase (5-LOX), cyclooxygenase (COX), leukotriene A(4) hydrolase (LTA4H) and prostaglandin E synthase (PGES), have been used as targets for anti-inflammatory drug discovery. Multi-ta...
Oxidants can reversibly increase the permeability of endothelium to ions and macromolecules. Oxidants also deplete ATP in cultured endothelial cells. We asked if oxidant-mediated ATP depletion, alone, accounted for the effects of oxidants on endothelial permeability to macromolecules. When porcine pulmonary artery endothelial cells were exposed to 2.5 mmol/LH2O2, ATP was depleted to 31.7% +/- 1...
Protease inhibitor (PI) may cause abnormal glucose metabolism, abnormal lipid metabolism, and metabolic syndrome in HIV-infected adults but less well studied in Asian adolescents. This cross-sectional study evaluated anthropometric factors, oral glucose tolerance test, and lipid profiles of perinatally HIV-infected Thai adolescents who had received PI-based antiretroviral therapy for at least 6...
Methotrexate-3H (MTX-3H) was accumulated against a con centration gradient by renal cortical slices. This accumulation was energy dependent, inhibited by metabolic inhibitors, Diamox, and high concentrations of ouabain. Several folie acid analogs containing the pteridine ring were inhibitors of this accumulation while certain weak organic acids were less striking inhibitors. This suggests that ...
Diabetes resulting from the low secretion of insulin and resistance, is a chronic metabolic disorder. Medication plant materials for treatment Mellitus advised as good source novel drug or leading to preparation drug. We investigated antidiabetic property fractions subfractions obtained ethyl acetate extract Trachyspermum ammi seeds. TLC analysis crude was done. Then column chromatography used ...
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