During hepatitis virus (HCV) chronic infection, extrahepatic manifestations are frequent and polymorphous. Initial description reported in large cohort of patients HCV-related autoimmune and/or lymphoproliferative disorders, from mixed cryoglobulinemia vasculitis to frank lymphomas. The relationship between HCV infection and such immune-related diseases has been formally demonstrated by epidemi...

Platelet abnormalities associated with hepatobiliary diseases include increased (thrombocytosis) and decreased (thrombocytopenia) numbers of platelets as well as abnormalities in function (thrombocytopathy or thrombasthenia). Hepatic diseases that are accompanied by platelet abnormalities include hepatitis, cirrhosis, portal hypertension, and neoplastic disorders both benign and malignant. The ...

Metabolic syndrome (MS) is a widespread polyethiological clustering characterized by metabolic, hormonal disorders and clinical manifestations that significantly increase the risk of developing cardiovascular diseases, atherosclerosis, type II diabetes other pathological conditions. An important role in development MS assigned to intestinal microbiota. To develop new therapeutic agents for corr...

Steatosis is a pivotal event in the initiation and progression of nonalcoholic fatty liver disease (NAFLD) which can be driven by peroxisome proliferator-activated receptor-α (PPAR-α) dysregulation. Through examining the effect of PPAR-α on fatty liver development, we found that PPAR-α is a target of miR-17-5p. Transgenic mice expressing miR-17 developed fatty liver and produced higher levels o...

In dairy cattle, the period of transition from late pregnancy to early lactation is characterized by dramatic changes in nutrient demand that necessitate coordinated changes in body tissue metabolism to meet requirements of energy, glucose and amino acids by the mammary gland (Bauman and Curie, 1980; Bell, 1995; Overton et al., 2001). Failure of the transition cow to appropriately adjust her me...

Abstract Liver damage is a common problem around the world, and pharmacocorrection of such disease carried out by administration various drugs. Natural synthetic thio-containing compounds are important in this respect. Most these, however, have side effects do not always meet criteria evidence-based medicine. Therefore, search for new drugs with hepatoprotective properties, characterized high e...

The liver serves a spectrum of essential metabolic and synthetic functions that are required for the transition from fetal to postnatal life. Processes essential to the attainment of adequate liver mass and function during fetal life include cell lineage specification early in development, enzymic and other functional modes of differentiation throughout gestation, and ongoing cell proliferation...

For the clinical neuroscientist, the metabolic en­ cephalopathies are a source of both optimism and frustration. This group of disorders is caused by failure of organs other than the brain that results in one of three basic mechanisms producing brain dysfunction: the presence of a toxin or accumula­ tion of a metabolic waste product, as in hyperam­ monemia or liver failure; deficiency of a nece...