Following the footprint of porphyrin-mediated photodynamic therapy (PDT), paramagnetic metalloporphyrins were originated as tumor seeking contrast agents (CAs) for magnetic resonance imaging (MRI). However, serial research has disproved their tumor selectivity, identified nonviable tissues as their real targets, and eventually elicited new applications in myocardial infarction delineation, tiss...

In this paper, the synthesis of a novel ionophore, chloro[5,10,15,20-tetrakis[2-(2,3,4,6-tetraacetyl-beta-D-glucopyranosyl)-1-O-phenyl]porphinato]manganese (MnT(o-glu)PPCl), and its application as a neutral carrier for a PVC membrane electrode are described. The MnT(o-glu)PPCl-based PVC membrane electrode shows a potentiometric responses to SCN- over a concentration range of 3.4 x 10(-7) - 1.0 ...

The preparation of undenatured apocytochrome bs and the apoprotein of an iodinated and acetylated derivative of cytochrome bs made possible the examination of the characteristics of hemei binding in this heme protein (2). A specific imidazole group on the apocytochrome was implicated in this reaction by stoichiometric titration of this single group on the iodinated and acetylated apoprotein wit...

Changes in membrane fluidity of porphyrin-doped liposomes have been investigated to assess the kinetics of the fluidization process. Metal complexes of tert-butylphenyl meso-substituted porphyrin, containing ions of Mg, Mn, Fe, Co, Ni and Cu, were used as dopants. Liposomes were obtained by sonication of hen egg yolk lecithin (EYL). Electron paramagnetic resonance (ESR) was applied using two sp...

6.4.1. Transition Metal Luminescent Complexes 2669 6.4.2. Metalloporphyrins 2669 6.4.3. Lanthanide Complexes 2670 6.4.4. Upconversion 2671 7. Fluorescence Lifetime Imaging Applications 2671 7.1. Cell Biology 2672 7.2. Tissue and Small Animal Lifetime Imaging 2672 7.2.1. Imaging of Cancer 2672 7.2.2. Diabetes and Kidney Pathologies 2674 7.2.3. Brain Tissue Analysis 2674 7.2.4. Blood Pathologies ...

Most lanthanide porphyrin derivatives exhibit ‘normal’ absorption spectra with Q and B bands. The rare earth ions have little effect on the absorption spectra, which are much like those of other closed-shell metalloporphyrins. However, their emission spectra vary according to which lanthanide ion is present. We observe two types of emissions: (i) a line emission arising from the lanthanide ion ...

Hemoglobin is composed of two pairs of globin chains to which are attached four iron-containing metalloporphyrins. Factors regulating hemoglobin synthesis include the availability of iron and the presence of heme. Heme production occurs by enzymatic synthesis and includes a step mediated by aminolevulinic acid dehydrase, which is zinc-dependent and, thus, susceptible to the toxic effects of oth...