Seven mouse monoclonal antibodies and the lectin Ulex europaeus, detecting blood group related antigens of the ABH and Lewis systems, have been used to determine the immunophenotype of human renal cell carcinomas. Immunohistochemical analyses have demonstrated that these antigenic systems are differentially expressed by distinct normal cell types and domains of the human nephron. In the present...

Renal cell carcinoma (RCC) affects patients by proliferating in the renal tubules, resulting in renal failure and concomitant urinalysis findings of blood, protein, casts, and abnormal cells in the urine. If untreated, it can spread to the lymph nodes, liver, and lungs. There is currently no proven tumor marker for RCC. The clinical case reported here describes the clinical laboratory findings ...

Oral cavity metastatic tumors derived from primary other corporal regions are rare, representing barely 1 % of all malignant tumors. Differential diagnosis these lesions is challenging due to the wide spectrum with similar clinical presentation and especially when presence a tumor goes undetected. We present case 55-year-old male painless in anterior maxillary region, vestibular gingiva palate,...

501. 3. Hammers HJ, Plimack ER, Infante JR, et al. Expanded cohort results from CheckMate 016: a phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC) [ASCO abstract 4516]. J Clin Oncol. 2015;33(15)(suppl). 4. McDermott DF, Sznol M, Sosman JA, et al. Immune correlates and long term follow up of a phase Ia study of MPDL3280A, an engineered PD-L1 anti...

Solitary metastasis of renal cell carcinoma (RCC) in the mediastinal lymph nodes is rare in patients without lung metastasis. We herein report a case of RCC with solitary mediastinal lymph node metastasis. A mass in the anterior mediastinum was found in the chest computed tomography (CT) scan of an asymptomatic 43-year-old-man. A mass on the right kidney was also revealed in an abdominal CT sca...

BACKGROUND Molecular targeted therapies have dramatically improved the prognosis of metastatic renal cell carcinoma. However, patients in whom the treatment could initially be effective will experience disease progression later. CASE PRESENTATION A 74-year-old Japanese man who was diagnosed with renal cell carcinoma with no evidence of metastasis presented to our hospital. He initially underw...

Metastatic non-colorectal cancer of the anal canal is a rare entity. To date, only four cases have been described in the literature. We present a 76-year-old man who was referred with an unusual perianal lesion. He had a history of renal cell carcinoma 7 years previously. Histologically, the lesion revealed clear cell carcinoma in keeping with metastasis. To our knowledge, this is only the seco...

Renal cell carcinomas make up 3% of all cancers and one in four patients is metastatic at time of diagnosis. This cancer is one of the most resistant to cytotoxic chemotherapy. Studies have shown that the efficiency of interferon-alpha and/or interleukin-2 based immune therapies is limited in patients with metastatic renal cell carcinoma but latest advances in molecular biology and genetic scie...