The article delineates the immediate and long-term results of 54 patients with non-organ tumors retroperitoneal space who witnesseda number complex treatments. Tumors a malignant nature were histologically verified by trepan biopsy in all (100%). In group,liposarcoma was 16 (29.6%) patients, leiomyosarcoma 17 (31.5%), fibrosarcoma 9 (16.7%), pleomorphic sarcoma 8 (14.8%), angiosarcoma 4 (7 , 4%...

Cancer of unknown primary (CUP) is metastatic cancer without a clinically detectable defined tumor site after an adequate diagnostic evaluation. It well recognized that CUP incidence occupies 1-5% all malignant epithelial tumors. Herein, we report case peritoneal carcinoma diagnosed as revealed by laparoscopic surgery.

BACKGROUND Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-Rex1) has been implicated in cancer growth, metastasis, and response to phosphatidylinositol 3-kinase (PI3K) inhibitor therapy. The aim of this study was to determine whether P-Rex1 expression differs between primary and metastatic human breast tumors and between breast cancer subtypes. DESIGN P-Rex1 expres...

BACKGROUND The rarity, delayed presentation, and diagnostic difficulty of small-bowel tumors prompted this study. STUDY DESIGN Charts were reviewed retrospectively for 85 patients with 89 small-bowel tumors (22 primary malignant, 23 primary benign, and 44 metastatic) over a 10-year period (1986-1996) at Louisiana State University Medical Center-Shreveport and two affiliated hospitals in Shrev...

PURPOSE Drug resistance in brain tumors is partially mediated by the blood-brain barrier of which a key component is P-glycoprotein, which is highly expressed in cerebral capillaries. Tamoxifen is a nontoxic inhibitor of P-glycoprotein. This trial assessed, in primary and metastatic brain tumors, the differential deposition of paclitaxel and whether tamoxifen could increase paclitaxel depositio...

BACKGROUND The prognosis of colorectal cancer patients is to a considerable extent determined by the metastatic potency of the primary tumor. However, despite the fact that liver metastases are the leading cause of death for cancer patients, the molecular basis still remains poorly understood and independent prognostic markers have not been established. MATERIALS AND METHODS Comparative genom...

background and aims: p504s (amacr) is a mitochondrial enzyme expressed in renal cell carcinoma. some of immunohistochemical markers in renal cell tumors are independent prognostic factor and show relation with histologic grading. amacr expression increases with higher histological grading in different tumors; however, in rcc it is not obvious. in this study, we tried to investigate if any relat...

Melanoma incidence and survival are age-dependent, with older patients having both higher rates worse outcomes. Here, we seek to examine age-dependent differences in mutational profiles of cutaneous melanoma, which may impact melanoma prognosis treatment-related Mutational 2263 were extracted from the American Association for Cancer Research Project Genomics Evidence Neoplasia Information Excha...

Distinguishing primary ovarian carcinoma from metastatic carcinoma to the ovary is often difficult by histologic examination alone. Recently an immunohistochemical marker CDX-2 was found to be of considerable diagnostic value in establishing the gastrointestinal origin of metastatic tumors. The aim of this study was to determine whether CDX-2 can distinguish between these malignancies. Paraffin...

Extracellular matrix metalloproteases and the fibrinolytic system are important protease systems interacting with each other in charge of remodeling and recycling of tissues. Their role in tumor invasion and metastasis is often discussed. In this study several metalloproteases such as MMP-1, MMP-3, MMP-9, and TIMP-1 together with molecules from the fibrinolytic system like uPA, its receptor uPA...