Several population studies have found an inverse association between flavonoid intake and risk of cardiovascular disease. These studies have resulted in the hypothesis that dietary flavonoids protect against cardiovascular disease. Many in vitro studies, studies using animal models and human intervention trials have been carried out to investigate how flavonoids might provide protection. Emergi...

Flavonoids are a class of chemically related polyphenols that are nearly ubiquitous in nature. Of the more-than 4000 flavonoids thus identified, citrus fruit-derived flavonoids are suggested to have an inverse association with the occurrence of coronary heart disease via their ability to reduce plasma cholesterol concentrations. Our current studies examined whether citrus flavonoids possess an ...

Flavonoids are ubiquitous in nature. They are also in food, providing an essential link between diet and prevention of chronic diseases including cancer. Anticancer effects of these polyphenols depend on several factors: Their chemical structure and concentration, and also on the type of cancer. Malignant cells from different tissues reveal somewhat different sensitivity toward flavonoids and, ...

Flavonoids or bioflavonoids are unique low molecular weight ubiquitous polyphenolic compounds produced by plants during their metabolic activities as a secondary metabolites and responsible for major organoleptic characteristics and health benefits of plant derived foods. The flavonoids are potent antioxidants agents and protect the cells by scavenging and inhibiting the production and initiati...

The effects of six flavonoids viz., apigenin, genistein, morin, naringin, pelargonidin and quercetin on the susceptibility of low-density lipoprotein (LDL) to oxidative modification were investigated. Flavonoids were added to plasma and incubated for 3 hr at 37 degrees C, and the LDL fraction was separated by ultracentrifugation. Oxidizability of LDL was estimated by measuring conjugated diene ...

Dried flowers of Trollius chinensis have long been used as an important traditional Chinese medicine. Previous studies have demonstrated the ability of T. chinensis flavonoids to reduce the proliferation of human breast cancer MCF-7 cells. The present study further investigated the influence of T. chinensis flavonoids on the growth and proliferation of MCF-7 cells and observed clear inhibitory ...

Two parasitic and achlorophyllous species, Aeginetia indica and Orobanche minor belonging to the family Orobanchaceae, were surveyed for flavonoids. The flowers and aerial parts of A. indica were exracted with MeOH and the flavonoids were isolated by various chromatographical techniques. Two anthocyanins were obtained from the flowers together with other flavonoids, and characterized as cyanidi...

The present study examined modifications of β-naphthoflavone (β-NF)-induced cytochrome P450 1A1 (CYP1A1) expression by flavonoids in mouse hepatocytes in primary culture. Some flavonoids (apigenin, chrysin, flavone, flavanone, galangin, luteolin, and naringenin) by themselves induced CYP1A1 mRNA expression, especially flavone which was even more effective than β-NF. The effect on β-NF-induced C...

A reliable solid-phase extraction – high-performance liquid chromatography (SPE-HPLC) method for the determination of flavonoids in European Bupleurum species B. baldense Turra and B. affine Sadler was developed. Extraction of aerial parts by ultrasound with 80% aqueous methanol and fractionation of flavonoids by means of SPE allowed a good recovery of analytes between 99 and 104%. The subseque...

Demyelination is a characteristic hallmark of the neuro-inflammatory disease multiple sclerosis. During demyelination, macrophages phagocytose myelin and secrete inflammatory mediators that worsen the disease. Here, we investigated whether flavonoids, naturally occurring immunomodulating compounds, are able to influence myelin phagocytosis by macrophages in vitro. The flavonoids luteolin, querc...