Bullous pemphigoid (BP) has been associated with an increase in venous thromboembolism due to impaired fibrinolysis. As plasma levels of plasminogen activator inhibitor type 1 (PAI-1) are elevated BP patients, this represents one possible mechanism. We sought better understand the role autoantibodies inducing a prothrombotic state. first reviewed our previous RNA-seq database BP-IgG treated ker...

The formation of the icosahedral phase (I-phase) as a secondary solidification phase in Mg-Zn-Y and Mg-Zn-Al base systems provides useful advantages in designing high performance wrought magnesium alloys. The strengthening in two-phase composites (I-phase + α-Mg) can be explained by dispersion hardening due to the presence of I-phase particles and by the strong bonding property at the I-phase/m...

Jul 3, 2001. Vancomycin overview and pharmacokinetic calculations. 15. The peak is the measured drug concentration AFTER distribution. Vd or Volume of mg/dl will greatly elevate the calculated creatinine clearance. This is . (Use minimum SCr of 1 mg/dL.. (round dose to nearest 10 mg for gentamicin/ tobramycin and to nearest 50 mg for amikacin). A trough level should be obtained within 30 minute...

A laboratory diagnosis survey of Clostridium difficile infection (CDI) was performed in Italy in 2012-2013. Questionnaires from 278 healthcare settings from 15 regions of Italy were collected and analysed. Eighty seven percent of the laboratories declared to routinely perform CDI diagnosis, 99% of them only after the clinician's request. Among the 216 laboratories providing information on the s...

OBJECTIVE Ferritin concentrations are often increased in patients with metabolic syndrome and type 2 diabetes mellitus, but few reports have examined the associations between ferritin and atherosclerosis. We investigated whether any relationship between ferritin and coronary artery calcium score (CACS) >0 (as a marker of atherosclerosis) was independent of potential confounders, such as iron-bi...

This paper presents an empirical analysis of the value of a coordinated market exchange mechanism. I present a model of e cient trading mechanisms under uncertainty, and develop a measure of the value of an inter rm trade agreement in the context of sequential `buy-versus-produce' decisionmaking by rms. The theory is applied to estimate the value of a formal trading institution in the Californi...