The facultative intracellular bacterial pathogen Listeria monocytogenes induces severe fetal infection during pregnancy. Little is known about the molecular mechanisms allowing the maternofetal transmission of bacteria. In this work, we studied fetoplacental invasion by infecting mice with various mutants lacking virulence factors involved in the intracellular life cycle of L. monocytogenes. We...

In order to elucidate the importance of the biological role of placental mammotropic hormones in the mammary development during pregnancy, the correlations between the number and weight of placentae and some indices of mammary development were examined using nulliparous C3H/He pregnant mice. On day 8 of pregnancy, the number of placentae was adjusted to 1-12 each by removing surgically the plac...

This paper reports a case of super pregnancy in a BALB/c mouse pregnant with 30 pups following induction of superovulation using a PMSG-hCG protocol. Superovulation was induced in 10 mice by injecting 5 IU PMSG followed by 5 IU hCG 48 hours later. Immediately after injection of hCG, animals were placed with males at a ratio of 1 to 1 for 24 hours. On day 14 after mating, animals were killed by ...

Campylobacter fetus is a gram-negative bacterial pathogen of both humans and animals. Two subspecies have been identified, Campylobacter fetus subsp. fetus and Campylobacter fetus subsp. venerealis, and there are two serotypes, A and B. To further investigate the genetic diversity among C. fetus strains of different origins, subspecies, and serotypes, we performed multiple genetic analyses by u...

A proportion of Pgp-1+ cells in the thymus have been shown to have progenitor activity. In adult AKR/Cum mice the total Pgp-1+ population in the thymus differs from that of the bulk of thymocytes and is antigenically heterogeneous when examined by flow cytometry. Pgp-1+ thymocytes are enriched for several minor cell populations compared to total thymocytes: B2A2-, interleukin-2-receptor+ (IL-2R...

toxoplasmosis is a worldwide infection which is commonly asymptomatic but can cause serious medical problems in immunocompromised individuals and fetus. the infection also causes considerable economic loss because of abortion in livestock, mostly in sheep and goats. dna vaccination may be a powerful approach against intracellular parasites such as toxoplasma gondii. the goal of this study was t...

objective(s): anti-epileptic drugs (aeds) have the potential to affect fetal development throughout pregnancy. considering the broad therapeutic indications of pregabalin (pgb), its potential teratogenic effects and the levels of homocysteine have been studied.   materials and methods: timed-pregnant mice received one of three doses of pgb (20, 40 or 80 mg/kg/day) or the vehicle control during ...

Presence of cross-reacting antibodies against embryonic cells and Rauscher leukemia cells was demonstrated in the sera collected from the C57BL/6 mice immunized with Rauscher leukemia cells, with the use of the indirect immunofluorescent test. Such cross-reacting antigenicity was also found in the SV40-transformed BLSV cells and AKR lymphoma cells. The antibody was completely absorbed with embr...

lorazepam has in increasingly being used in our country in recent years. pharmacologically, lorazepam belongs to the benzodiazepines known for their wide neurotropic properties. there have been several studies on the side effects of the drug as stress disorders, tumors, preconvulsive activities in case of epileptic attacks, overdose, and behavioral problems, but little is known regarding the te...