The effects of phenobarbital on development of some microsomal enzymes and neutral lipid were studied in mouse liver during a period of rapid cell differentiation. Specific alterations attributable to phenobarbital were identified in developing liver and used as markers for the onset of certain aspects of cell maturation. This investigation was designed to determine (1) the earliest development...

We examined the use of the mouse Pc-3 ESTR (expanded simple tandem repeat) locus and 72 human microsatellite loci as potentially sensitive biomarkers for mutagenic exposures to germ cells in mice and humans respectively. In the mouse work, we treated male mice with TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; a chemical known to induce congenital anomalies in humans and mice) and, analysed the...

objective: carthamus tinctorius l. (safflower) is a member of the asteraceae family which is used as a food additive but also has medicinal applications. this study investigated its effects on placental histomorphology and survival of mice neonates. materials and methods: eighty balb/c pregnant mice were randomly distributed into one control and three experimental groups (n=20). the control gro...

BACKGROUND The presence of antibodies to thyroglobulin (Tg) is associated with fetal loss even in the absence of thyroid dysfunction. The aim of this study was to examine whether active immunization with Tg could elicit anti-Tg autoantibodies and reproductive failure without interfering with thyroid function. METHODS BALB/c mice that were immunized with human Tg in complete Freund's adjuvant ...

Trachea and lung parenchyma from human fetuses were transplanted subcutaneously into immune-deprived mice. After seven to 10 weeks they were removed for histological examination. It was found that the tissues continued to grow and develop along similar lines to those which they would have followed in utero.

Although the biokinetics, metabolism, and chemical toxicity of methyl tert-butyl ether are well known, little attention was paid to the potential toxic effects of MTBE on reproduction and development in mammals. To evaluate the effects of MTBE on pregnant animals, two groups (control and test) of NMRI mice were chosen. In test group 500 and 1000 mg/Kg of it were administered intraperitonealy at...

Pasteurella pneumotropica was isolated from the uteri, fetuses, lungs, and spleens of aborting Swiss Carworth mice. Male mice in the colony carried P. pneumotropica in pharynges, testes, and seminal vesicles. Normal pregnant and nongravid females carried P. pneumotropica in the eye of 1 and in the uteri of 4 of 11. Pregnant mice from another colony did not abort when injected with P. pneumotrop...

Epidemiological studies have shown increased incidence of hypertension and coronary artery disease in growth-restricted fetuses during their adult life. A novel animal model was used to test the hypothesis regarding the role of an abnormal uterine environment in fetal programming of adult vascular dysfunction. Mice lacking a functional endothelial nitric oxide synthase (NOS3-/-KO, where KO is k...