The reticuloendothelial stimulant glucan, a beta-1,3-polyglucose component of the cell wall of Saccharomyces cerevisiae, was evaluated for its ability to modify Staphylococcus aureus-induced lethality in normal and leukemic mice. In normal mice the intravenous injection of glucan (0.45 mg per mouse) 7 and 4 days prior to intravenous challenge with S. aureus (1.0 x 10(9)) resulted in a significa...

Introduction: Epidermal growth factor receptor (EGFR) has been shown to play a critical role in tumor cell growth and its overexpression has been observed in many epithelial tumors. In the field of cancer vaccine research, displaying the peptide mimotope on the surface of phage particles has shown promising results. Methods: In this study using m13-PVIII phage display system, two constructs we...

Background Xenotransplantation of ovary can help individuals who may be at sterility risk after chemotherapy or radiotherapy of diseases such as cancer. Moreover, this technique can be used to preserve fertility of valuable animal species. The aim of the present study was to preserve balb/c mice ovarian tissue by xenotransplantation into uterus of rat that is immune suppressed. MaterialsAndMeth...

Microneedle Arrays In article number 2100128, Jamil Azzi, Natalie Artzi, and co-workers present a theranostic microneedle-based platform for the simultaneous delivery of immune modulators sampling skin interstitial fluid to monitor response therapy. Using model allogeneic transplant in mice, they show that microneedle-mediated therapy can help regulate system locally, without inducing systemic ...

Currently, the sole treatment option for patients with heart failure is transplantation. The battle of prolonging graft survival and modulating innate and adaptive immune responses is still being waged in the clinic and in research labs. The transcription factor Nrf2 controls major cell survival pathways and is central to moderating inflammation and immune responses. In this study the effect of...

A model of aspiration lung injury was developed in WT C57BL/6 mice to exploit genetically modified animals on this background, i.e., MCP-1(-/-) mice. Mice were given intratracheal hydrochloric acid (ACID, pH 1.25), small nonacidified gastric particles (SNAP), or combined acid plus small gastric particles (CASP). As reported previously in rats, lung injury in WT mice was most severe for "two-hit...