1673 available suggests that convulsions are the only serious complication of acute zimeldine overdosage. [Sales of zimeldine in all countries were discontinued by Astra Pharmaceuticals in September 1983 because of the company's concern about reports of serious neurological side effects including the Guillain Barr6 syndrome.] I Dawling S, Braithwaite RA. Simplified method for monitoring tricycl...

Trichophyton violaceum, a less common and geographically restricted infection is reported in a 18-day-old neonate. The diagnosis was made by potassium hydroxide of skin scraping examination and confirmed by culture. The patient was treated successfully with miconazole nitrate application. A large family with crowded living was considered the main predisposing factor.

According to data on the imidazole antimycotics at present on the market, none of these products satisfactorily fills the gaps which exist in the treatment for mycoses of internal organs, although they have brought considerable progress in the topical treatment of mycoses. On the basis of their very broad spectrum and high intensity of activity under suitable test conditions, and the comparativ...

GENERIC NAME PAGE Amphotericin B 596 Butoconazole 601 Capsofungin 601 Ciclopirox 602 Clotrimazole 600 Econazole 601 Fluconazole 598 Flucytosine 601 Griseofulvin 602 Itraconazole 599 Ketoconazole 599 GENERIC NAME PAGE Miconazole 600 Naftifine hydrochloride 602 Nystatin 598 Oxiconazole nitrate 601 Sulconazole nitrate 601 Terbinifine hydrochloride 602 Terconazole 601 Tioconazole 601 Tolnaftate 602...

In order to develop new approaches to treatment of infections due to Pseudallescheria boydii, the in vitro antifungal activity of amphotericin B alone and in combination with miconazole, itraconazole, and fluconazole was studied. Combinations of amphotericin B and antifungal azoles were synergistic, additive, or indifferent in their interaction against P. boydii. Antagonism was not observed.

To test the hypothesis that PKCβ-induced reactive oxygen species (ROS) underlie the vascular dysfunction in diabetes, we examined the effects of LY333531 (LY), a specific PKCβ inhibitor, on arachidonic acid (AA)-mediated dilation in small coronary arteries from streptozotocin-induced diabetic rats. This study was designed to determine whether diabetes impairs AA-induced vasodilation of small co...

Malassezia pachydermatis is associated with dermatomycoses and otomycosis in dogs and cats. This study compared the susceptibility of M. pachydermatis isolates from sick (G1) and healthy (G2) animals to azole and polyene antifungals using the M27-A3 protocol. Isolates from G1 animals were less sensitive to amphotericin B, nystatin, fluconazole, clotrimazole and miconazole.

Application of glutamate to glial cell cultures stimulates the formation and release of epoxyeicosatrienoic acids (EETs) from arachidonic acid by cytochome P-450 epoxygenases. Epoxygenase inhibitors reduce the cerebral vasodilator response to glutamate and N-methyl-D-aspartate. We tested the hypothesis that epoxygenase inhibitors reduce the somatosensory cortical blood flow response to whisker ...

Oculomycosis may be divided into the orbital infections of phycomycosis of Aspergillus and other species and the infections of the globe. The latter comprise endogenous, post-surgical or traumatic intra-ocular infections and direct infections of the cornea: these are the commonest form of oculomycosis. They are not easy to differentiate from other, more common causes of septic infection of the ...