Clinical vignette: A 29-year-old woman is referred for management of infertility. After menarche at age 12, menses occurred irregularly for a year and then became regular. She initiated use of oral contraceptive pills at the age of 18, then stopped at age 27 to try to conceive. Evaluation revealed hyperprolactinemia with serum prolactin of 90 ng/ml; pituitary MRI showed a 6-mm microadenoma. Oth...

Cushing’s disease due to adrenocorticotropin (ACTH)-secreting macroadenomas is rare. The aim of this study was to evaluate the clinical characteristics and biochemical assessment of patients with corticotroph macroadenomas,and the early and late outcomes of transsphenoidal surgery as the first surgical approach during a long-term follow-up. We performed a retrospective review of 20 patients wit...

OBJECTIVES To report on the phenotypic spectrum and clinical management of Chinese patients suffering from the rare autosomal dominant colorectal cancer syndrome of familial adenomatous polyposis. DESIGN Analysis of prospectively collected data from the database of a regional registry. SETTING The Hereditary Gastrointestinal Cancer Registry, Hong Kong. PARTICIPANTS One hundred and eight p...

PURPOSE To investigate the prevalence and physical basis of a specific form of MR susceptibility artifact that may be seen in the pituitary gland near the junction of sellar floor and sphenoidal septum. MATERIALS AND METHODS Coronal, T1-weighted MR images of the pituitary glands in 50 subjects without clinical evidence of pituitary or sphenoidal sinus disease were reviewed to determine the pr...

OBJECTIVE To determine the frequency of indication of the GH suppression test and pituitary magnetic resonance imaging (MRI) in patients with clinical suspicion of acromegaly with GH concentrations > 0.4 µg/L despite normal serum IGF-1. SUBJECTS AND METHODS A total of 160 patients with clinical suspicion of acromegaly with normal IGF-1 were studied. RESULTS Basal GH > 0.4 µg/L was observed ...

Background and Importance: Intravascular papillary endothelial hyperplasia (IPEH), a pathologic variant of thrombus organization, is driven by endothelial cell proliferation along surfaces of aggregate fibrin, resulting in the formation of papillary structures. Intracranial IPEH is very rare, and is infrequently encountered at the cranial base. Progressive lesional growth results in mass effect...

OBJECTIVE To explore equation, if any, between findings of magnetic resonance imaging of pituitary gland and serum prolactin level. METHODS The retrospective, descriptive study was conducted at the Department of Radiology, Aga Khan University Hospital, Karachi, and related to patients' records from April 19, 2006 to April 23, 2009. Seventy patients underwent magnetic resonance imaging of brai...

OBJECTIVE To describe three cases of Cushing's disease in children with multiple endocrine neoplasia type 1 (MEN1), as clinical manifestations of MEN1 are very rare in childhood. DESIGN AND METHODS A retrospective review of three cases of Cushing's disease diagnosed between 1997 and 1999. Genetic screening for MEN1 gene mutation was performed in each patient. RESULTS An ACTH-secreting micro...

The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the PI3K/Akt signaling pathway. Only one Chinese study described somatic mutations and amplification o...

A 41-year-old man with acromegaly was suffering from chronic, progressive backache and aware of reduction in his body height. Endocrine studies revealed increased glucose non-suppressible serum growth hormone (GH) and serum prolactin (PRL). Pituitary microadenoma was detected by a computerized axial tomogram and subsequently resected by trans-sphenoidal adenomectomy. The tumor proved to be a mi...