Background: Microbeam Radiation Therapy (MRT) induces a transient vascular permeability window, which offers novel drug-delivery system for the preferential accumulation of therapeutic compounds in tumors. MRT is preclinical cancer treatment modality that spatially fractionates synchrotron X-rays into micrometer-wide planar microbeams can induce permeability, especially immature tumor vessels, ...

In previous communications the authors have described the cellular and subcellular responses to ultraviolet irradiation directed to whole Chang liver cells and to portions of Chang liver cells (3-6). Two sources of ultraviolet have been utilized in these studies. One source was a mercury arc lamp the output of which was passed through a grating monochromator, and the second source was the ultra...

This paper describes the fabrication and integration of light-induced dielectrophoresis for cellular manipulation in biological microbeams. An optoelectronic tweezers (OET) cellular manipulation platform was designed, fabricated, and tested at Columbia University's Radiological Research Accelerator Facility (RARAF). The platform involves a light induced dielectrophoretic surface and a microflui...

The understanding of complex radiation responses in biological systems, such as non-targeted effects as represented by the bystander response, can be enhanced by the use of genetically amenable model organisms. Almost all bystander studies to date have been carried out by using conventional single-cell in vitro systems, which are useful tools to characterize basic cellular and molecular respons...