نتایج جستجو برای: microtubule

تعداد نتایج: 31980  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1985
M Caplow R Reid

We propose a role for GTP hydrolysis in microtubule assembly in which the GTPase reaction serves to stabilize tubulin subunits in the microtubule. The GTPase reaction in tubulin subunits containing GTP at microtubule ends is presumed to occur predominately in subunits at one of the interfaces between a cap of GTP-containing tubulin subunit and a core of GDP-containing tubulin subunit in the mic...

Journal: :Current Biology 2006

Journal: :Bioorganic & Medicinal Chemistry 2014

Journal: :Journal of Cell Biology 1966

Journal: :Nature Cell Biology 2012

Journal: :Current Biology 2013

Journal: :Communicative & Integrative Biology 2010

Journal: :Scientific Reports 2015

Journal: :The Journal of Cell Biology 1997
Harald Felgner Rainer Frank Jacek Biernat Eva-Maria Mandelkow Eckhard Mandelkow Beat Ludin Andrew Matus Manfred Schliwa

Microtubules are flexible polymers whose mechanical properties are an important factor in the determination of cell architecture and function. It has been proposed that the two most prominent neuronal microtubule-associated proteins (MAPs), tau and MAP2, whose microtubule binding regions are largely homologous, make an important contribution to the formation and maintenance of neuronal processe...

Journal: :The Journal of Cell Biology 1997
Hiroshi Sato Toshio Nagai Dhandapani Kuppuswamy Takahiro Narishige Masaaki Koide Donald R. Menick George Cooper IV

Increased microtubule density, for which microtubule stabilization is one potential mechanism, causes contractile dysfunction in cardiac hypertrophy. After microtubule assembly, alpha-tubulin undergoes two, likely sequential, time-dependent posttranslational changes: reversible carboxy-terminal detyrosination (Tyr-tubulin left and right arrow Glu-tubulin) and then irreversible deglutamination (...

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