Silymarin ‘milk thistle’ (Silybum marianum) plant, has been used for years treatment of different diseases such as liver and gallbladder disorders, protecting against snake bite insect stings, mushroom poisoning alcohol abuse. antioxidant, anti-lipid peroxidative, antifibrotic, anti-inflammatory, immunomodulatory, regeneration activities. The cardioprotective activities silymarin were primarily...

Liver dysfunction often is associated with an imbalance in the production and removal of free radicals derived from oxygen and nitrogen and has been managed clinically with antioxidant supplements, including silymarin extract derived from milk thistle. The potential for enhanced bioavailability of a phytosome complex containing phosphatidylcholine and silybin, the primary active flavonolignan i...

The antifungal activity of ethanol extract of Silybum marianum was investigated invitro against three strains of Rhizoctonia solani at different concentrations (5, 10, 15 and 20%). Bioassay of extract was conducted by poisoned food technique with three replications. The findings showed that strain of R. solani (Eggplant) was susceptible to concentrations of S. marianum more than other strains i...

The endophytic fungus Penicillium restrictum was isolated from the stems of a milk thistle (Silybum marianum) plant. In culture, the fungus produced distinct red guttates, which have been virtually uninvestigated, particularly from the standpoint of chemistry. Hence, this study examined the chemical mycology of P. restrictum and, in doing so, uncovered a series of both known and new polyhydroxy...

The use of botanical dietary supplements has grown steadily over the last 20 years despite incomplete information regarding active constituents, mechanisms of action, efficacy, and safety. An important but underinvestigated safety concern is the potential for popular botanical dietary supplements to interfere with the absorption, transport, and/or metabolism of pharmaceutical agents. Clinical t...

Quantitative prediction of herb-drug interaction risk remains challenging. A quantitative framework to assess a potential interaction was used to evaluate a mechanism not previously tested in humans. The semipurified milk thistle product, silibinin, was selected as an exemplar herbal product inhibitor of raloxifene intestinal glucuronidation. Physiologically based pharmacokinetic (PBPK) model s...

Silybum marianum (L.) Gaertn. is an important medicinal plant of family Compositae, commonly known as Milk-thistle, or St. Mary’s thistle. The plant and its extracts are reported to possess hepatoprotective, antioxidant, [1] anticancer, [2] antiinflammatory and antidiabetic properties. It contains flavonolignan Silymarin, which is an important bioactive principle having anticancer, antiinflamma...

Previously we have shown that perorally administered silymarin, a mixture of flavonolignans extracted from the seeds of Silybum marianum, possesses a hypocholesterolemic effect in rats fed high cholesterol diet enriched with fat. The aim of this paper was to complete the data concerning peroral and parenteral administration of silymarin. The rats fed standard laboratory diet did not respond to ...

Substituted pyrazinecarboxamides markedly influenced production of flavonolignans in Silybum marianum callus and suspension cultures. In this study the effect of two compounds, N-(3-iodo-4-methylphenyl)pyrazine-2-carboxamide (1) and N-(3-iodo-4-methylphenyl)-5-tert-butyl-pyrazine-2-carboxamide (2), as abiotic elicitors on flavono-lignan production in callus culture of S. marianum was investigat...