Finkel MS, et al. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science (Wash. DC) 257: 387, 1992. YamadaT, et al. Therapeutic effect of anti-tumor necrosis factor-oc antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus. Circulation 89: 846, 1994. Packer M for The Promise Study Research Group : Effect of oral milrinone on morta...

This study tests the hypothesis that particulate (p) guanylyl cyclase (GC) and soluble (s) GC are involved in the distinct roles for the regulation of cGMP-PDE-cAMP signaling and of mechanical and secretory functions in the heart. Experiments were performed in perfused beating rabbit atria. C-type natriuretic peptide (CNP) and SIN-1, an NO donor, or BAY 41-2272 (BAY), a direct activator for sGC...

Pulmonary hypertension is a major reason for elevated perioperative morbidity and mortality, even in non-cardiac surgical procedures. Patients more often experience serious complications, such as right-ventricular failure, arrhythmias, and early postoperative death. Preoperatively patients should be thoroughly prepared for the intervention and allowed plenty of time for consideration. All speci...

LY186126 was found to be a potent inhibitor of type IV cyclic AMP phosphodiesterase located in the sarcoplasmic reticulum of canine cardiac muscle. This compound, a close structural analogue of indolidan (LY195115), was prepared in high specific activity, tritiated form to study the positive inotropic receptor(s) for cardiotonic phosphodiesterase inhibitors such as indolidan and milrinone. A hi...

OBJECTIVE To determine whether transient hypoxia in neonatal rats has long-lasting effects on inotropic stimulation of the adult heart. METHODS The hearts of adult male Sprague-Dawley rats (89+/-1 (S.E.M.) days, 432+/-5 g) were studied. Half the animals had been subjected to neonatal hypoxia (FiO(2)=0.12, days 1-10) while the others had not. The peak response of left ventricular pressure (LVP...

RS-1893, 2-[2-chloro-4-(2,3,4,5-tetrahydro-3-oxo-6-pyridazinyl)]-phenoxy-N- (2-(2-morpholinoethyl)-acetamide, is a newly synthesized compound whose structure is different from that of cardiac glycosides and beta-stimulants. The in vitro cardiotonic action of RS-1893 was about 3 times more potent than that of milrinone. This action is most likely due to inhibition of phosphodiesterase-III, as ha...