نتایج جستجو برای: minicircle
تعداد نتایج: 402 فیلتر نتایج به سال:
In this study we aim to correct mutations within COL7A1 that cause malfunction, reduction or complete absence of type VII collagen in the skin’s basement membrane zone (BMZ), leading dystrophic epidermolysis bullosa (DEB), a severe and rare skin blistering disease associated with high risk cancer as well increased mortality. Therefore, use 3’-RTMS6m repair molecule develop safe, non-viral, non-...
A new version of targeted minicircle producer system for EBV-positive human nasopharyngeal carcinoma
Using a minicircle DNA primer-template, the wild-type catalytic subunit of herpes simplex virus type 1 (HSV-1) DNA polymerase (pol) was shown to lack significant strand displacement activity with or without its processivity factor, UL42. However, an exonuclease-deficient (exo ) pol (D368A) was capable of slow strand displacement. Although UL42 increased the rate (2/s) and processivity of strand...
Six short G-rich intergenic regions in the maxicircle of Leishmania tarentolae are conserved in location and polarity in two other kinetoplastid species. We show here that G-rich region 6 (G6) represents a pan-edited cryptogene which contains at least two domains edited independently in a 3'-to-5' manner connected by short unedited regions. In the completely edited RNA, 117 uridines are added a...
Trypanosoma cruzi (Schyzotrypanum, Chagas, 1909), and Chagas disease are endemic in captive-reared baboons at the Southwest Foundation for Biomedical Research, San Antonio, Texas. We obtained PCR amplification products from DNA extracted from sucking lice collected from the hair and skin of T. cruzi-infected baboons, with specific nested sets of primers for the protozoan kinetoplast DNA, and nu...
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