In acute myeloid leukaemia (AML), further prognostic determinants are required in addition to cytogenetics to predict patients at increased risk of relapse. Recent studies have indicated an internal tandem duplication (ITD) in the FLT3 gene may adversely affect clinical outcome. The studies reported in this thesis evaluated the impact of a FLT3/ITD on outcome in 854 patients treated in UK MRC A...

We study the minimal density of letters in infinite square-free words. First, we give some definitions of minimal density in infinite words and prove their equivalence. Further, we propose a method that allows to strongly reduce an exhaustive search for obtaining lower bounds for minimal density. Next, we develop a technique for constructing square-free morphisms with extremely small density fo...

fundamental importance of evidence in the criminal procedure revealsnecessity of a deep study of that and its principles. one of the progressiveprinciple governing of evidence in criminal procedure, is free proof .that isinvolving free obtaining and evaluation of evidence. according to thisadvanced principle that there are no restriction in presentation andacceptance of evidence unless with sti...

In this paper we consider the problem of creating minimal, deadlock-free routing algorithms, where a routing algorithm is said to be minimal if it uses only shortest paths. In particular, we examine the possibility of creating scalable algorithms that use only a constant number of buuers per node. Minimal, scalable, deadlock-free routing algorithms are known for many important networks includin...

In this article, element free Galerkin method is used for static analysis of thin micro/nanoscale plates based on the nonlocal plate theory. The problem is solved for the plates with arbitrary boundary conditions. Since shape functions of the element free Galerkin method do not satisfy the Kronecker’s delta property, the penalty method is used to impose the essential boundary conditions. Discre...