Abstract Background and aim Malignant involvement of the pericardium is seen in 1 to 20 percent autopsies patients with cancer. The most common metastatic tumor involving lung cancer [1]. We aimed distinguish origin pericardial fluid effusion (i.e. pericarditis vs cancer) based on miRNAs expression peripheral blood plasma. Method 8 hospitalized for collection neoplastic aetiology (lung cancer)....

background and aims: several studies have shown that there is greater number of viruses in deep periodontal pockets than in normal gingival sulcus. we also know that virus may have an important role in induction of il-1β secretion by different human cells. in this study we intended to determine the capacity of herpes simplex virus type 1 to stimulate il-1β secretion in human gingival keratinocy...

In this paper, 4 microRNAs and their targets were predicted through a de novo prediction procedure in the genome of Porcine Reproductive and Respiratory Syndrome virus. Through clustalW analysis, these 4 microRNAs were recognized as novel PRRSV derivate microRNAs. Target prediction results showed PRRSV mir-1, 2 and 4 have total 16 targets in porcine 3’ UTR database. These targets could be divid...

Dieser Beitrag präsentiert ein webbasiertes Serious Game, das Studierenden in medizinischen Studiengängen die Möglichkeit gibt, Arzt-PatientenGespräche in Form von Rollenspielen mit simulierten Patienten selbständig und systematisch zu trainieren. Der Phase der Immersion (Rollenspiel) folgt dabei eine Phase der distanzierten Reflexion, um den lernförderlichen Perspektivenwechsel zu unterstützen...

objective: cardiac cell differentiation with the help of mirnas has recently opened a promising window for the restoration of myocardial infarction. independent mir-1-2/133a-1 and mir-206/133b clusters are known to be expressed in cardiac and skeletal muscles, respectively. mir-133b differs from mir-133a by only one nucleotide. the sequence similarity of these two mirnas suggests that they targ...

Background: Colorectal and breast carcinoma are frequently diagnosed cancers. At advanced stages, cancers metastasize to certain organs resulting in loss of function these organs, eventually death. Therefore, there is a specific need for the prognosis Currently, microRNAs (miRNAs), have emerged as new target cancer-specific biomarker. Objective: To examine expression miRNA primary metastatic co...

Introduction Polychlorinated biphenyls (PCBs), organic lipophilic pollutants that accumulate through diet and increase with age, have been associated polycystic ovary syndrome (PCOS) shown to affect microRNA (miRNA) expression. This work aimed determine if PCBs were circulating miRNAs whether there any correlations serum PCB/miRNA levels hormonal changes. Methods 29 non-obese PCOS healthy contr...

in the recent years deregulation for micrornas expression pattern have emerged as a possible molecular factor for carcinogenesis. it has been reported that the expression of mir-9 was down-regulated in human gastric adenocarcinoma. to figure out the molecular mechanism of this down regulation, the methylation status in promoters of mir-9 family loci were compared in the human gastric adenocarci...

A progressive subclass of early-stage non-muscle-invasive bladder cancer (NMIBC) frequently recurs and progress into invasive carcinoma, thus decreasing the overall survival rate NMIBC. However, therapeutic development for NMIBC has been challenging due to lack molecularly validated in vivo models agents targeting its genetic vulnerability. We herein characterized an interventional model reveal...