Pancreatic cancer is one of the most lethal malignancies worldwide. To illustrate the pathogenic mechanism(s), we looked into the expression and function of miR-329 associated with pancreatic cancer development. It was found that miR-329 expression was downregulated in the pancreatic cancer patients who demonstrated significantly shorter overall survival than the patients having upregulated exp...

The intronic microRNA (miR)-342 has been proposed as a potent tumor-suppressor gene. miR-342 is found to be downregulated or epigenetically silenced in multiple different tumor sites, and this loss of expression permits the upregulation of several key oncogenic pathways. In several different cell lines, lower miR-342 expression results in enhanced proliferation and metastasis potential, both in...

Increasing evidence suggests that epilepsy is the result of synaptic reorganization and pathological excitatory loop formation in the central nervous system; however, the mechanisms that regulate this process are not well understood. We proposed that microRNA-132 (miR-132) and p250GAP might play important roles in this process by activating the downstream Rho GTPase family. We tested this hypot...

Kernel density estimators are the basic tools for density estimation in non-parametric statistics.  The k-nearest neighbor kernel estimators represent a special form of kernel density estimators, in  which  the  bandwidth  is varied depending on the location of the sample points. In this paper‎, we  initially introduce the k-nearest neighbor kernel density estimator in the random left-truncatio...

The Ras homolog (Rho) family of small GTPases comprise several proteins with prominent roles in regulation cell cycle transition, migration, and remodeling actin cytoskeleton. Expression these is regulated by factors among them are long non-coding RNAs (lncRNAs). impact lncRNAs on Rho signaling can be exerted through direct modulation expression or influencing miRNAs that negatively regulate GT...

Article history: Received 31 October 2016 Accepted 1 November 2016 Available online 9 November 2016 (both miR-675-5p and miR-675-3p) expression in clinical samples. MiR-675-5p was undetectable in TCGA samples, while miR-675-3p expression correlated with H19 levels, but was no predictor either for overall or disease-free survival. At least in their model system that Calin and coworkers used, H19...

Objective(s): To investigate the effect of miR-103 on the angiogenesis of ischemic stroke rats via targeting vascular endothelial growth factor (VEGF) at the molecular level. Materials and Methods: Rat models had received the middle cerebral artery occlusion (MCAO) or sham operation before grouping, and cell models of oxygen-glucose deprivation (OGD) were performed. FITC-dextran, matrigel, and ...

Background and Aims: Chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Research has shown that in CLL, microRNAs can have function as oncogenes or tumor suppressors. Some studies demonstrated that the expression of microRNA-93 (miR-93) and microRNA-330 (miR-330) have been changed in several can...

We consider n observations from the GARCH-type model: S = σ2Z, where σ2 and Z are independent random variables. We develop a new wavelet linear estimator of the unknown density of σ2 under four different dependence structures: the strong mixing case, the β- mixing case, the pairwise positive quadrant case and the ρ-mixing case. Its asymptotic mean integrated squared error properties are ...