OBJECTIVE To explore what triggers an elevated body temperature of > or =40.0 degrees C in some women given misoprostol, a prostaglandin E1 analogue, for postpartum haemorrhage (PPH). DESIGN Post hoc analysis. SETTING One tertiary-level hospital in Quito, Ecuador. POPULATION A cohort of 58 women with a fever of above 40 degrees C following treatment with sublingual misoprostol (800 microg...

BACKGROUND The pharmacokinetics of vaginal misoprostol as a dry tablet or as a tablet moistened with normal saline or with acetic acid were studied. METHODS For this study, 42 women requesting termination of pregnancy at gestational age of <12 weeks were recruited and received 400 µg vaginal misoprostol tablets. They were randomized into three groups: (i) dry tablets, (ii) tablets moistened w...

Introduction Misoprostol is used for the medical management of miscarriage as it is more effective in the early stages of pregnancy. Letrozole has an anti-estrogen effect and is used for the pretreatment of miscarriage with misoprostol. Aim The aim of this study was compare the efficacy and safety of letrozole with placebo pretreatment in the medical management of first trimester missed misca...

BUCHHEIT, TERESA MARIE. Effects of the Prostaglandin Analogue Misoprostol on TNFAlpha Release by Activated Equine Leukocytes. (Under the direction of Dr. Samuel Jones). The magnitude of LPS-induced equine health problems cannot be over-estimated since endotoxemia is intimately involved in the pathogenesis of gastrointestinal disorders that cause colic, the leading cause of death in adult horses...

BACKGROUND & OBJECTIVE Medical abortion though legalized in India, is still not very popular. A disadvantage of medical abortion is the longer duration of bleeding compared with surgical abortion which may reduce acceptability. Due consideration needs to be given to the issues related to medical abortion for improving the reproductive health status of women suffering from consequences of unsafe...

PURPOSE To establish whether misoprostol (a synthetic prostanoid) is effective in improving intestinal metaplasia of dyspeptic patients. PATIENTS Of the 206 dyspeptic patients without Helicobacter pylori, 18 (7.1%) had histological evidence of intestinal metaplasia (2 presented mild metaplasia, 9 moderate and 7 severe). They were treated with misoprostol 200 mg twice daily for six months and,...

OBJECTIVE To compare the effectiveness of titrated orally and vaginally administered misoprostol for induction of labour. STUDY DESIGN Unmasked randomized controlled trial. SETTING Department of Obstetrics and Gynaecology University of Zimbabwe, Harare. SUBJECTS Pregnant women with singleton foetus in cephalic presentation booked for induction of labour, were randomized to receive titrate...

Background: To assess the efficacy and safety of Misoprostol 800ug per rectally in active management of third stage of labour. Methods: In this prospective study, a total of 200 pregnant women who delivered after 34 weeks of gestation at a tertiary teaching institute were included. The women were divided in to 4 groups by using randomization depending on the drug given at birth of anterior shou...

OBJECTIVE To evaluate whether a combination of misoprostol and oxytocin more effectively reduces blood loss during and after cesarean delivery than does oxytocin alone among women with known risk factors for postpartum hemorrhage (PPH). METHODS A prospective, randomized, double-blind, placebo-controlled trial was performed at a tertiary care center in Kolkata, India, between October 2012 and ...

OBJECTIVE This comparative study was aimed at determining the effectiveness of oral Misoprostol compared with intravenous Ergometrine and intravenous Oxytocin in reducing vaginal bleeding following surgical evacuation for first trimester abortions. MATERIALS AND METHODS This was a single-blind placebo-controlled study in which patients with first trimester uncomplicated abortions were divided...