Introduction Inhibition of mitochondrial respiration has been associated with the cytotoxicity of NO right from the beginning of NO research [1,2]. Recent findings have confirmed the importance of mitochondrial inhibition, but put the previous research into a new context. Here we review our findings that: (a) NO reversibly inhibits O2 consumption by isolated cytochrome oxidase, mitochondria, ne...

Barilius bendelisis is an important food fish and a demanding ornamental species in India. Despite its great economic importance, several wild populations have been suffering drastic reduction. The genetic variability within population is extremely useful for gathering information on individual’s identity, breeding patterns, degree of relatedness and disturbance of genetic variation among them....

Cytochrome b, coded by mitochondrial DNA, is one of the cytochromes involved in electron transport in the respiratory chain of mitochondria. Cytochrome b is a critical intermediate in amitochondrial death pathway. To revealwhether cytochromebof themosquitoAedes aegypti (L.) (Diptera: Culicidae) (AeaCytB) is developmentally regulated, we used real-time quantitative polymerase chain reaction (qPC...

The phylogenetic relationships among seven Callosciurus species from the Indochina Peninsula, including C. honkhoaiensis which is endemic to Hon Khoai Island, were studied using complete mitochondrial cytochrome b gene sequences (1140 bases). We primarily focused on position of pygerythrus, distributed in western part peninsula. identified two main lineages: 1) caniceps, honkhoaiensis, inornatu...

Serpulidae Rafinesque, 1815 is a speciose group of polychaetes that all inhabit calcareous tubes. The family was traditionally subdivided into Serpulinae, Filograninae, and Spirorbinae. Recent phylogenetic analyses have suggested both Filograninae Serpulinae are paraphyletic, though with limited sampling. Here we report the first analysis based on comprehensive sampling genera (though excluding...

Chloroacetaldehyde (CAA) is a chlorination by-product in finished drinking water and a toxic metabolite of a wide variety of industrial chemicals (e.g. vinyl chloride) and chemotherapeutic agents (e.g. cyclophosphamide and ifosfamide). In this research, the cytotoxic mechanisms of CAA in freshly isolated rat hepatocytes were investigated.CAA cytotoxicity was associated with reactive oxygen spec...

Arsenic exposure mainly through food and water has been shown to be associated with increased incidence of numerous cancers and non-cancer harmful health. It is also used in cancer chemotherapy and treatment of several cancer types due to its apoptogenic effects in the various cancer and normal cell lines. We have already reported that liver is the storage site and important target organ in As ...

During apoptosis, cytochrome c is released into the cytosol as the outer membrane of mitochondria becomes permeable, and this acts to trigger caspase activation. The consequences of this release for mitochondrial metabolism are unclear. Using single-cell analysis, we found that when caspase activity is inhibited, mitochondrial outer membrane permeabilization causes a rapid depolarization of mit...

Ilicicolin H is an antibiotic isolated from the "imperfect" fungus Cylindrocladium iliciola strain MFC-870. Ilicicolin inhibits mitochondrial respiration by inhibiting the cytochrome bc(1) complex. In order to identify the site of ilicicolin action within the bc(1) complex we have characterized the effects of ilicicolin on the cytochrome bc(1) complex of Saccharomyces cerevisiae. Ilicicolin inh...

Sebastian C. Obasi* School of Biological Sciences, Abia State University P. M.B 2000 Uturu Abia State, Nigeria * Present address: IPC Department, Raw Materials Research and Developm ent Council, PMB 232 Garki, Abuja, FCT, Nigeria Z. Naturforsch. 56c, 278-282 (2001); received August lO/October 27, 2000 Scopoletin, Aflatoxin B^ Mitochondrial, Cytochrome c Reductases The in vitro effects of the to...