Complexation reactions between methylthymol blue and Fe , A l ,Ga , 1n a nd TI ions have been studied in buffer aqueous solutions of pH 5.0 at 2S°C by a spectrophotometric technique. The conditional stepwise stability constants of the resulting 1:l and 1:2 (metal-to-ligand) complexes were determined from the absorbance-mole ratio data at three different wavelengths of the visible sp...

We report thermal, X-ray diffraction (XRD) and cytotoxicity studies of complexes of fluconazole (FCZ) with Cu (II), Fe(II), Cd(II), Co(II), Ni(II), and Mn(II). From XRD measurements, FCZ and its metal complexes were identified as polycrystalline. Marked differences in the X-ray patterns of drug and its metal complexes revealed that the complexes are indeed different compounds and not just the m...

Mixed ligand complexes of dioxouranium(VI) and thorium(IV) in the proportion 1:1:1 and 1:2:1 have been synthesized using 8-hydroxyquinoline as a primary ligand and L-proline and 4-hydroxy-L-proline as secondary ligands, respectively. The metal complexes have been characterized on the basis of elemental analysis, molar conductance, magnetic, spectral and thermal studies. The molar conductance st...

Rare-earth complexes are attractive catalyst systems due to their low cost, low toxicity and high reactivity. Modular ligand sets are ideal for complex formation since the steric and electronic properties of the resultant metal complexes can be easily varied. This thesis explores the structure and reactivity of new yttrium amidate complexes, which combine the highly reactive metal with the modu...

Mixed ligand Th(IV) complexes of the type [M(Q)2LNO3.H2O] have been synthesized using 8-hydroxyquinoline (HQ) as a primary ligand and N- and/or O- donor amino acids (HL) such as L-alanine, L-phenylalanine, L-serine and L-tyrosine as secondary ligands. The metal complexes have been characterized on the basis of elemental analysis, electrical conductance, room temperature magnetic susceptibility ...

In this study, the complexation reaction between Alprazolam (ALP) and metal ions (Zn2+, Ni2+, Cu2+ and Co2+) was investigated by using spectrophotometry in ethanol solvent. The stoichiometry of M+/ALP complexes was calculated by applying the Job, molar ratio and Continuous Changes methods and the relevant diagrams were plotted for each metal ions in each method. The results show that the obtain...

Mixed ligand Cu(II) complexes of the type [M(Q)(L)]-2H2O have been synthesized using 8-hydroxyquinoline (HQ) as a primary ligand and N- and/or O-donor amino acids (HL) such as L-threonine, L-proline, L-hydroxyproline, L-isoleucine and L-serine as secondary ligands. The metal complexes have been characterized on the basis of elemental analysis, electrical conductance, room temperature magnetic s...

Mixed ligand Ni(II) complexes of the type [M(Q)(L) x 2H2O] have been synthesized by using 8-hydroxyquinoline (HQ) as a primary ligand and N- and/or O- donor amino acids (HL) such as L-serine, L-isoleucine, L-proline, 4-hydroxy-L-proline and L-threonine as secondary ligands. The metal complexes have been characterized on the basis of elemental analysis, electrical conductance, room temperature m...

Mixed ligand complexes of transition metal ions such as Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) have been synthesized using 4-(Benzeneazo)salicylaldehyde, 2-amino-4-nitrophenol and nitrates of respective metal ions. The synthesized complexes have been characterized with infra red (IR), electronic, and H-NMR Spectra, molar conductance and magnetic susceptibility measurements at room t...

this study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (ts) inhibitor. the designed scaffold is a combination of nucleobase, amino acid and aziridine structures. the candidates are docked into ts and three dna double strand structures and evaluated based on their binding interaction energies and ligand efficienci...