A key function of human eosinophils is to secrete cytokines, chemokines and cationic proteins, trafficking, and releasing these mediators for roles in inflammation and other immune responses. Eosinophil activation leads to secretion of pre-synthesized granule-stored mediators through different mechanisms, but the ability of eosinophils to secrete extracellular vesicles (EVs), very small vesicle...

OBJECTIVES To investigate the role of pericytes in constructing the malformed microvessels (MVs) and participating microvascular architecture heterogeneity of glioma. METHODS Forty human glioma tissue samples (WHO grade II-IV) were included in present study. Observation of blood vessel patterns, quantitative analysis of endothelial cells (ECs)- and pericyte-labeled MVs and comparison between ...

Objectives: To evaluate the association between multivitamin supplements (MVS) and the severity of periodontitis in older women (PMW) and to delineate demographic, lifestyle factors, anthropometric measurements and pre-existing diseases associated with MVS intake. Methods: Retrospective, cross-sectional study was conducted using a database of over 900 PMW. Subjects were divided into two groups ...

Expanded storage is offered as a relatively inexpensive way of using high speed processor storage to minimize I/O operations. Under many circumstances, expanded storage achieves this objective. In some situations, the expanded storage algorithms may not yield the expected benefits. In a few situations, expanded storage can cause severe performance problems. This paper describes the concepts and...

M icrovesicles (MVs), small circular membrane fragments shed from the cell surface or released from the endosomal compartment, play an important and underappreciated role in cell-to-cell communication.1 This intriguing MV-mediated communication system emerged very early during evolution and served as a template for the further development of cell-to-cell interaction mechanisms involving soluble...

We protect ourselves from airborne cross-infection in the indoor environment by supplying fresh air to a room by natural or mechanical ventilation. The air is distributed in the room according to different principles: mixing ventilation, displacement ventilation, etc. A large amount of air is supplied to the room to ensure a dilution of airborne infection. Analyses of the flow in the room show ...

Cell-to-cell communication is a fundamental process for development and maintenance of multicellular organisms. Diverse mechanisms for the exchange of molecular information between cells have been documented, such as the exchange of membrane fragments (trogocytosis), formation of tunneling nanotubes (TNTs) and release of microvesicles (MVs). In this study we assign to Fas signalling a pivotal r...

BACKGROUND AND PURPOSE This investigation identified ventilation distribution, gas mixing, lung function, and arterial blood oxyhemoglobin saturation (SpO2) physiologic responses to 2 independent airway clearance treatments, high-frequency chest wall oscillation (HFCWO) and low positive expiratory pressure (PEP) breathing, for subjects who had cystic fibrosis (CF) and who were hospitalized duri...

We have measured dynamic lung compliance or static lung thorax compliance, functional residual capacity (FRC), and two indices of pulmonary gas mixing (pulmonary clearance delay (PCD) and single breath alveolar mixing efficiency (SBAME)) in 25 children in the supine and lateral decubitus position during nitrous oxide-halothane anaesthesia. Fifteen children (5 month-8 yr) breathed spontaneously ...