Normative variation in mathematical aptitude (MA) is relevant to many aspects of societal functioning, in particular for occupations in science, technology, engineering and mathematics (STEM). Though elements of numerosity have been identified in some animals, complex MA is uniquely human. Several studies, using a variety of designs, have investigated the heritability of MA, and the extreme end...

In the last decades, strategy variability and flexibility have become major aims in mathematics education. For children with mathematical learning disabilities (MLD) it is unclear whether the same goals can and should be set. Some researchers and policy makers advise to teach MLD children only one solution strategy, others advocate stimulating the flexible use of various strategies, as for typi...

Available biomedical ontologies and knowledge bases currently lack formal and standards-based interconnections between disease, disease vector, and drug treatment vocabularies. The PNNL Medical Linked Dataset (PNNL-MLD) addresses this gap. This paper describes the PNNLMLD, which provides a unified vocabulary and dataset of drug, disease, side effect, and vector transmission background informati...

The reliability-based heuristic search methods for maximum likelihood decoding (MLD) generate test error patterns (or, equivalently, candidate codewords) according to their heuristic values. Test error patterns are stored in lists and its space complexity is crucially large for MLD of long block codes. One of the well-known heuristic search methods for MLD is the A decoding algorithm proposed b...

Parity helps us determine whether an arithmetic equation is true or false. The current research examines the development of sensitivity to parity cues in multiplication in typically achieving (TA) children (grades 2, 3, 4 and 6) and in children with mathematics learning disabilities (MLD, grades 6 and 8), via a verification task. In TA children the onset of parity sensitivity was observed at th...

The focus of this paper is on a parallel algorithm for solving the transport equations in a slab geometry using multigrid. The spatial discretization scheme used is a nite element method called Modiied Linear Discontinuous scheme (MLD). The MLD scheme represents a lumped version of the standard Linear Discontinuous scheme (LD). The parallel algorithm was implemented on the Connection Machine 2 ...

M leukodystrophy (MLD) is an autosomal recessive disorder, caused by deficiency of arylsulfatase A (cerebroside sulfatase A, ASA), which results in accumulation of sulfatides, mainly in the brain and peripheral nerves. The estimated frequency of MLD from previous reports is 1 in 40,000 cases. The deficiency in ASA activity is caused by mutations in the ASA gene. The deficiency is systemic and a...

PURPOSE Limits on mean lung dose (MLD) allow for individualization of radiation doses at safe levels for patients with lung tumors. However, MLD does not account for individual differences in the extent or spatial distribution of pulmonary dysfunction among patients, which leads to toxicity variability at the same MLD. We investigated dose rearrangement to minimize the radiation dose to the fun...

RATIONALE AND OBJECTIVES To evaluate the relationship between measurements of lung volume (LV) on inspiratory/expiratory computed tomography (CT) scans, pulmonary function tests (PFT), and CT measurements of emphysema in individuals with chronic obstructive pulmonary disease. MATERIALS AND METHODS Forty-six smokers (20 females and 26 males; age range 46-81 years), enrolled in the Lung Tissue ...

[(14)C]Stearic acid-labeled cerebroside sulfate (CS) was presented to cultured skin fibroblasts in the media. After endocytosis into control cells 86% was readily metabolized to galactosylceramide, ceramide, and stearic acid, which was reutilized in the synthesis of the major lipids found in cultured fibroblasts. Uptake and metabolism of the [(14)C]CS into cells from typical and atypical patien...