During wound-healing, cells are required to migrate rapidly into the wound site via a proteolytically generated pathway in the provisional matrix, to produce new extracellular matrix, and, subsequently, to remodel the newly formed tissue matrix during the maturation phase. Two classes of molecules cooperate closely to achieve this goal, namely, the matrix adhesion and signaling receptors, the i...

Odontogenic myxoma is a benign neoplasm, which presents local invasiveness and tendency for recurrence. Matrix metalloproteinases (MMPs) 2 and 9 are involved in tumor invasion. Thus, the aim of this study was to analyze the expression and activity of these MMPs in odontogenic myxoma in vivo and in vitro. Three cases of odontogenic myxoma and cultured cells derived from this tumor (Mix1 cell lin...

A large class of discrete-event and hybrid systems can be described by a max-min-plus-scaling (MMPS) model, i.e., a model in which the main operations are maximization, minimization, addition, and scalar multiplication. Further, Model Predictive Control (MPC), which is one of the most widely used advanced control design methods in the process industry due to its ability to handle constraints on...

OBJECTIVES Abdominal aortic aneurysm (AAA) wall is characterized by degradation of extracellular matrix through matrix metalloproteinases (MMPs), chronic inflammatory cell infiltration and extensive neovascularization. So far, MMP expression within AAA wall in association with infiltrates and neovascularization has not yet been studied. METHODS Vessel walls of 15 AAA patients and 8 organ dono...

Matrix metalloproteinases (MMPs) are zinc-containing proteinases that participate in tissue remodeling under physiological and pathological conditions. To test the involvement of bacterial proteinases in tissue injury during bacterial infections, we investigated the activation potential of various bacterial proteinases against precursors of MMPs (proMMPs) purified from human neutrophils (proMMP...

An air pollutant consists of any atmospheric substance that may harm humans, animals, vegetation or material. Various air pollutants have been reported, differing in their physicochemical characteristics. They can be grouped into four categories: gaseous pollutants (e.g. ozone, sulfur dioxide, oxides of nitrogen, carbon monoxide and volatile organic compounds), persistent organic pollutants, he...

Failed therapies directed against matrix metalloproteinases (MMP) in cancer patients may be attributed, in part, to lack of diagnostic tools to differentiate between pro-MMPs and active MMPs, which indicate whether a treatment is efficacious or not. Because galectin-3 is cleavable in vitro by MMPs, we have developed differential antibodies recognizing its cleaved and noncleaved forms and tested...

In situ hydrogelation of injectable precursors upon biological stimulus is relevant to generate hydrogels under mild conditions and, potentially, at a side interest. Here, it shown that hydrolytic enzymes can be used initiate the formation covalent hydrogel networks, realizing cleavage-leading-to-gelation strategy. For this purpose, two-component system used, consisting 4-arm polyethylene glyco...

Experimental observations suggest that in the vicinity of the glioma-host interaction zone glioma cells secrete MMPs that dissolve the ECM composition and disturb the balance of the brain tissue [3]. In order to restore the natural balance, healthy brain cells try and produce more ECM components as well as secreting tissue inhibitor of the MMPs (TIMPs) [12]. In this paper we present a mathemati...