نتایج جستجو برای: modeling challenges
تعداد نتایج: 670589 فیلتر نتایج به سال:
A computational cognitive model of Web navigation is a working computer system that simulates human users searching for items in a Web site. A fully working model must automate aspects of human perception, decision making and physical control. To successfully predict human behavior, these automated processes must be consistent with the cognitive and physical limitations of human users. Predicte...
The functional role of the observed neuronal variability (the disparity in neural responses across multiple instances of the same experiment) is again receiving close attention in Computational and Systems Neuroscience (e.g., Durstewitz et al., 2010; Moreno-Bote et al., 2011; Oram, 2011; Beck et al., 2012; Churchland and Abbott, 2012; Brunton et al., 2013; Masquelier, 2013; Mattia et al., 2013;...
Nanotoxicity has become of increasing concern since the rapid development of metal nanoparticles (NPs). Aquatic nanotoxicity depends on crucial qualitative and quantitative properties of nanomaterials that induce adverse effects on subcellular, tissue, and, organ level. The dose-response effects of size-dependent metal NPs, however, are not well investigated in aquatic organisms. In order to de...
In this paper, we identify main challenges for domain specific modeling frameworks. Arbitrary abstract to concrete syntax mapping enables the toolsmith to create visual representation to complex logical models with the possibility to determine what detail to show and what to hide in a flexible way. Interactive model simulation based on a model transformation architecture allows for the design t...
Substantial improvements are required in the current suite of numerical models if we are to better understand the present ocean biogeochemical state and predict potential future responses to anthropogenic perturbations. At present, major impediments to marine biogeochemical modeling include the inadequate representation of multi-element cycling and community structure, large-scale physical circ...
In this special section we report on the workshop Standards in Emotion Modeling held in August 2011, Leiden, The Netherlands. An important goal of this workshop was to identify challenges related to the development and evaluation of computational models of affective processes. These challenges were approached from a psychological and a computational modeling perspective. In this introduction we...
Metabolism is a core process of every cell providing the energy and building blocks for all other biological processes. Mathematical models and computational tools have become essential for unraveling the complexity of cellular metabolism (Heinemann and Sauer, 2010). Models integrate current knowledge on a biological system in an unambiguous manner and allow simulating cellular responses to gen...
Over the past several decades, it has become increasingly clear that functionally active RNA molecules are not restricted to a few unusual examples that are involved in translation (such as transfer RNA and ribosomal RNA) and RNA processing (like spliceosomal RNAs, self-splicing ribozymes, selfcleaving ribozymes and ribonuclease P). Rather, large and small regulatory RNAs are transcribed in abu...
Understanding the relationship between soil biodiversity, habitat, and function is one of the main issues of soil-ecological research. The description of spatiotemporal distributions of soil organisms at relevant scales and in relation to their activity is a prerequisite to understand and quantify the factors that control soil functions. Species distribution models can help to explain the funct...
After nearly two decades of debate and fundamental disagreement, topdown and bottom-up energy-economy modelers, sometimes referred to as modeling ‘tribes’, began to engage in productive dialogue in the mid-1990s (IPCC 2001). From this methodological conversation have emerged modeling approaches that offer a hybrid of the two perspectives. Yet, while individual publications over the past decade ...
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