نتایج جستجو برای: molecular subtypes
تعداد نتایج: 668175 فیلتر نتایج به سال:
The 2 2 model of perfectionism examines the relation between four subtypes of perfectionism and psychological adjustment (Gaudreau & Thompson, 2010). Researchers have investigated subtypes of perfectionism using common multivariate statistical analyses. The development of a new measure is warranted to evaluate whether individuals can, with a decent degree of certainty, assess by themselves thei...
γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition. In specific brain cells, such as in hippocampus, one of subtypes GABAARs, δ subunit containing GABAARs (δ-GABAARs), is predominantly expressed and located extrasynaptic or perisynaptic positions. δ-GABAARs mediate a slow constant inhibitory curre...
Nodular melanoma is the second most common subtype of melanoma. Unlike other subtypes, nodular characterized by early vertical growth rather than typical initial radial melanomas. As a result, presents clinically in more aggressive phenotype. Given its nature and intrinsic ability to mimic benign lesions, modified acronym has been developed allow clinicians better evaluate, diagnose treat earli...
Motivation Whole genome expression profiling of large cohorts of different types of cancer led to the identification of distinct molecular subcategories (subtypes) that may partially explain the observed inter-tumoral heterogeneity. This is also the case of colorectal cancer (CRC) where several such categorizations have been proposed. Despite recent developments, the problem of subtype definiti...
PURPOSE The aim of this study was to investigate the breast cancer (BC) molecular subtypes according to its surrogate immunohistochemistry (IHC) markers. We conducted a preliminary study, to correlate the clinical pathological profiles and molecular subtypes of breast cancer in Luanda, Angola. METHODS From January 2011 to 30 December 2014, 140 consecutive cases of microscopically confirmed in...
BACKGROUND Tumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according to cell origin theory. However, anatomic distribution of unique molecular subtypes was not widely investigated. The relationship between molecular phenotype and histological subgroup were also vague based on tumor location. Our group focuses on the study...
Glioblastoma (GBM) heterogeneity in the genomic and phenotypic properties has potentiated personalized approach against specific therapeutic targets of each GBM patient. The Cancer Genome Atlas (TCGA) Research Network has been established the comprehensive genomic abnormalities of GBM, which sub-classified GBMs into 4 different molecular subtypes. The molecular subtypes could be utilized to dev...
BACKGROUND Breast cancer may be classified into distinct molecular subtypes based on gene expression profiling and/or immunophenotypic characteristics. Aim of the study was to investigate prevalence, clinicopathologic features and overall survival (OS) of molecular subtypes, in a large European population-based study. PATIENTS AND METHODS All invasive breast cancers from 2003 to 2007 were sel...
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