BACKGROUND Hypertrophic cardiomyopathy (HCM) is a primary cardiac disease with a diverse clinical spectrum, in which many of the abnormal structural and pathophysiologic features are consequences of inappropriate left ventricular hypertrophy. METHODS We analyzed the amount, distribution and structure of the cardiac collagen network in transmural sections of the ventricular septum (thickness 1...

CONTEXT The standard criteria used to evaluate tumor response, the Response Evaluation Criteria in Solid Tumors (RECIST), were developed to assess tumor shrinkage after cytotoxic chemotherapy and may be limited in assessing response to biologic agents, which have a cytostatic mechanism of action. OBJECTIVE To validate novel tumor response criteria based on morphologic changes observed on comp...

Abstract Functioning in media discourse as reference points for shaping people’s worldview, sociocultural stereotypes are considered cognitive-linguistic phenomena, formed the process of evaluative categorization. A lexical item that represents a stereotype is determined study nomen stereotype. The aim paper to outline strategies formation found American discourse. Nomina by phonetic, morpholog...

BACKGROUND Osteosarcomas (OS) are aggressive neoplasms with a wide range of morphologic patterns. MATERIALS AND METHODS OS cases (primary and xenotransplanted) with paraffin blocks available were collected and included in tissue microarrays (TMAs). A morphologic evaluation including the different passages in mice was carried out according to the new WHO criteria. In addition, TMAs were analyz...

OBJECTIVE To assess the outcome on management recommendations of a comparative approach vs a morphologic approach in evaluating dermoscopic images of lesions from a series of patients with multiple nevi. DESIGN In a 2-step study, 6 experienced dermoscopists were asked to provide management recommendations (excision or follow-up) for a series of lesions from patients with multiple nevi based o...

The aim was to clarify whether enhancement effects of the liver parenchyma in the hepatobiliary phase (HP) of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging were correlated with the morphological grading of the severity in cirrhosis. A total of 62 patients with chronic hepatitis or cirrhosis underwent Gd-EOB-DTPA-enhanced MR imaging. Relative enhan...

Background: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) provides functional information on the microcirculation in tissues by analyzing the enhancement kinetics which can be used as biomarkers for prostate lesions detection and characterization.Objective: The purpose of this study is to investigate spatiotemporal patterns of tumors by extracting semi-quantitative as well as w...

BACKGROUND AND PURPOSE Gray matter heterotopia have been divided into three groups based on clinical and imaging characteristics: subependymal, subcortical, and band heterotopia. Nonetheless, subcortical heterotopia can have variable morphologic findings. The purpose of this study was to perform a morphologic analysis of a series of cases of subcortical heterotopia based on MR images, to correl...

The World Health Organization (WHO) classification of hematopoietic neoplasms, published in 2001, included the new category of “Myelodysplastic/ Myeloproliferative Diseases,” intended to accommodate those myeloid neoplasms that simultaneously showed features of chronic myeloproliferative disorders and myelodysplastic syndromes. Typically, myelodysplastic syndromes (MDS) are clonal neoplastic di...