Body fluids and tissues in 16 methadone (MTD)-associated fatalities were investigated to find out whether analysis of MTD and its metabolite 2-ethylidine-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) following enantioselective separation of both compounds may assist in the interpretation of MTD findings. Individual case histories were shortly described. R- and S-MTD as well as R- and S-EDDP conce...

Incremental search algorithms, such as Generalized FringeRetrieving A* and D* Lite, reuse search trees from previous searches to speed up the current search and thus often find cost-minimal paths for series of similar search problems faster than by solving each search problem from scratch. However, existing incremental search algorithms have limitations. For example, D* Lite is slow on moving t...