Despite nerve-sparing radical prostatectomy, nerve damage and erectile dysfunction (ED) prevail, and preventing neurodegeneration is of great importance. Neurotrophic factors and neurite outgrowth were characterized in major pelvic ganglia (MPG) following bilateral cavernous nerve injury (BCNI). Young male Sprague-Dawley rats underwent sham or BCNI surgery, and the intracavernosal pressure to m...

Methylation of DNA CpG sites is a major mechanism of epigenetic gene silencing and plays important roles in cell division, development and carcinogenesis. One of its regulators is the 64-residue C-terminal Transcriptional Repressor Domain (the TRD) of MBD1, which recruits several repressor proteins such as MCAF1, HDAC3 and MPG that are essential for the gene silencing. Using NMR spectroscopy, w...

Mixed Presence Groupware (MPG) supports both colocated and distributed participants working over a shared visual workspace. It does this by connecting multiple single-display groupware workspaces together through a shared data structure. Our implementation and observations of MPG systems exposes two problems. The first is display disparity, where connecting heterogeneous tabletop and vertical d...

Undertaken study deals with any vulnerable changes by the radioprotective drug 2-mer captopropionylglycine, after administering in variable concentration (20, 50, 100, 200 and 500 mg/kg body weight) of the liver of adult mice at 1, 3, 7 and 14 days interval. The lower doses, 20 and 50 mg/kg body-weight of MPG did not affect the liver at all while at higher doses of 100, 200 and 500 mg/kg body-w...

Repair of oxidative stress- and inflammation-induced DNA lesions by the base excision repair (BER) pathway prevents mutation, a form of genomic instability which is often observed in cancer as 'mutation hotspots'. This suggests that some sequences have inherent mutability, possibly due to sequence-related differences in repair. This study has explored intrinsic mutability as a consequence of se...

biodegradable nanoparticulate carriers, have important potential applications for administration of therapeutic molecules. chitosan based nanoparticles have attracted a lot of attention upon their biological properties such as biodegradability, biocom-patibility and bioadhesivity. the aim of the present investigation was to describe the synthesis and characterization of novel biodegradable nano...

A systematic approach for constructing interpretable fuzzy model based on reduction methodology is proposed. Fuzzy clustering algorithm, combined with least square method, is used to identify initial fuzzy model with overestimated rule number. Orthogonal least square algorithm and similar fuzzy sets merging are then applied to remove redundancy of the fuzzy model. In order to obtain high accura...

This article gives an exact expression for parallax adjustments to apparent elevation of objects at finite distances beyond the Earth atmosphere suitable for use at the very low elevation angles required by the Deep Space Network (DSN) Services Preparation Subsystem (SPS) Metric Prediction Generator (MPG). The parallax depends entirely on the astronomical refraction function and does not requir...