High quality metabolic mapping of several important brain metabolites (NAA, Cho, Cr, Ins, Glu) was achieved for a 64×64 matrix with a 3.4×3.4×12 mm voxel size in six healthy subjects (Fig.1, Fig.2). Subcutaneous lipids were suppressed by an additional factor of ~12 compared to standard 32×32 matrix (Fig.3). Most notably, the ultra-short TE increased the signal-to-noise ratio of J-coupled resona...

Magnetic resonance spectroscopic imaging (MRSI) is an imaging modality used for generating metabolic maps of the tissue in-vivo. These maps show the concentration of metabolites in the sample being investigated and their accurate quantification is important to diagnose diseases. However, the major roadblocks in accurate metabolite quantification are: low spatial resolution, long scanning times,...

Multiparametric MR (mpMR) imaging is rapidly evolving into the mainstay in prostate cancer (PCa) imaging. Generally, the examination consists of T2-weighted sequences, diffusion-weighted imaging (DWI), dynamic contrast-enhanced (DCE) evaluation, and less often proton MR spectroscopy imaging (MRSI). Those functional techniques are related to biological properties of the tumor, so that DWI correl...

Purpose Magnetic resonance spectroscopic imaging (MRSI) is an imaging modality used for studying tissues in-vivo in order to assess and quantify metabolites for diagnostic purposes. However, long scanning times, low spatial resolution, poor signal-to-noise ratio (SNR) and the subsequent noise-sensitive non-linear model fitting are major roadblocks in accurately quantifying the metabolite concen...

OBJECTIVE To investigate the association of an indicator of hippocampal function with severity of depression symptoms in temporal lobe epilepsy. METHODS We evaluated 31 patients with video/EEG-confirmed temporal lobe epilepsy using creatine/N-acetylaspartate ratio maps derived from a previously validated (1)H magnetic resonance spectroscopic imaging ((1)H-MRSI) technique at 4.1 T. We also ass...

The exploration of novel imaging methods that have the potential to improve specificity for the identification of malignancy is still critically needed in breast imaging. Changes in physiologic alterations of soft tissue water associated with breast cancer can be visualized by magnetic resonance (MR) imaging. However, it is unlikely that a single MR parameter can characterize the complexity of ...

Truncation artifacts arise in magnetic resonance spectroscopic imaging (MRSI) of the human brain due to limited coverage of k-space necessitated by low SNR of metabolite signal and limited scanning time. In proton MRSI of the head, intense extra-cranial lipid signals "bleed" into brain regions, thereby contaminating signals of metabolites therein. This work presents a data acquisition strategy ...

Modern imaging techniques like computerized tomography (CT) and magnetic resonance imaging (MRI) have revolutionized diagnostics in all fields of medicine, enabling physicians to obtain detailed scans of tissues with minimal discomfort to their patients. These technologies are vital at all stages in the treatment of patients who have brain tumors: in the initial diagnosis, for surgical planning...