Lipid-based nanocarriers have been extensively investigated for drug delivery due to their advantages including biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity. However, the shortcomings of traditional lipid-based such as insufficient targeting, capture by reticuloendothelial system, fast elimination limit efficiency therapeutic efficacy. Therefore, a series multifunction...

a great challenge in using natural polysaccharide as drug delivery system is their fast drug release. the purpose of the present study was to prepare and evaluate chitosan oligosaccharide (cho)-de-estrifiedtragacanth (det) core-shell nanoparticles for controled release of water soluble drugs. cho-det nanoparticles were prepared by microemulsion method and characterized by ft-ir spectroscopy. si...

microspheres formulated from poly (d,l-lactic-co-glycolide) (plga), a biodegradable polymer, have been extensively evaluated as a drug delivery system. in this study, the preparation, characterization and drug release properties of the plga microspheres were evaluated. simvastatin (sim)-loaded plga microspheres were prepared by oil-in-water emulsion/solvent evaporation method. the microspheres ...

Enzyme-responsive, hybrid, magnetic silica nanoparticles have been employed for multifunctional applications in selective drug delivery and intracellular tumor imaging. In this study, doxorubicin (Dox)-conjugated, enzyme-cleavable peptide precursors were covalently tethered onto the surface of uniform silica-coated magnetic nanoparticles through click chemistry. This enzyme-responsive nanoparti...

In the present study, a cell-penetrating peptide, the transactivating transcriptional factor (TAT) domain from HIV, was linked to PEGylated multi-walled carbon nanotubes (MWCNTs) to develop a highly effective antitumor drug delivery system. FITC was conjugated on MWCNTs-polyethylene glycol (PEG) and MWCNTs-PEG-TAT to provide fluorescence signal for tracing the cellular uptake of the nanocarrier...

Multifunctional nanomedicine is emerging as a highly integrated platform that allows for molecular diagnosis, targeted drug delivery, and simultaneous monitoring and treatment of cancer. Advances in polymer and materials science are critical for the successful development of these multi-component nanocomposites in one particulate system with such a small size confinement (<200 nm). Currently, s...

In this report, we have designed a simple and efficient green chemistry approach for the synthesis of colloidal silver nanoparticles (b-AgNPs) that is formed by the reduction of silver nitrate (AgNO3) solution using Olax scandens leaf extract. The colloidal b-AgNPs, characterized by various physico-chemical techniques exhibit multifunctional biological activities (4-in-1 system). Firstly, bio-s...