BACKGROUND The inheritance pattern in most cases of autism is complex. The risk of autism is increased in siblings of children with autism and previous studies have indicated that the level of risk can be further identified by the accumulation of multiple susceptibility single nucleotide polymorphisms (SNPs) allowing for the identification of a higher-risk subgroup among siblings. As a result o...

Variable screening has emerged as a crucial first step in the analysis of high-throughput data, but existing procedures can be computationally cumbersome, difficult to justify theoretically, or inapplicable to certain types of analyses. Motivated by a high-dimensional censored quantile regression problem in multiple myeloma genomics, this article makes three contributions. First, we establish a...

|We consider the problem of multiple sequence alignment: given k sequences of length at most n and a certain scoring function, nd an alignment that minimizes the corresponding \sum of pairs" distance score. We generalize the divide-and-conquer technique described in 1,2], and present new ideas on how to use eecient search strategies for saving computer memory and accelerating the procedure for ...

In this paper we present a methodoly for the scoring of punctuation annotated texts, as well as a preliminary system to perform the task. We modify SCLITE’s scoring methodology to support scoring of punctuation. Using this methodology, we show that the error rate of an initial automatic system is comparable to annotator inconsistency. However, the use of multiple references allows us to differe...