Knowledge-based systems have a wide commercial applicability. However, a credible validation methodology for knowledge-based systems is currently lacking. Our research addresses the feasibility of partitioning rule-based systems into a number of meaningful units to enhance the comprehensibility, maintainability and reliability of expert systems software. Preliminary results have shown that no s...

Vaults are 13 megadalton ribonucleoprotein particles composed largely of the major vault protein (MVP) and two high molecular weight proteins, p240 and p193, and a small vault RNA (vRNA). Increased levels of MVP expression, vault-associated vRNA, and vaults have been linked directly to multidrug resistance (MDR). To further define the putative role of vaults in MDR, we produced monoclonal antib...

OBJECTIVE The study was designed to determine the effect of low frequency (2.5Hz) intraurethral electrical stimulation on bladder capacity and maximum voiding pressures. MATERIALS AND METHODS The experiments were conducted in 15 virgin female Sprague-Dawley rats (220-250g). The animals were anesthetized by intraperitoneal injection of urethane (1.5g/kg). Animal care and experimental procedure...

Mitral valve prolapse (MVP) has long been the subject of intense discussions regarding prognosis and follow-up tactics. In most cases, this condition a benign prognosis. However, recent autopsy studies have shown risks developing sudden cardiac death (SCD) in some subgroups patients who clinical phenomenon. The proposed literature review uses population with MVP highest probability life-threate...

AIMS The present study was to assess the reduction of right ventricular pacing (RVP) by pacemaker algorithms of Managed Ventricular Pacing (MVP) and Search AV+ (SAV+) interval over a period of 12 months. METHODS AND RESULTS A total of 385 patients indicated for a dual-chamber pacemaker (DC-PM) were enrolled in the prospective, randomized COMPARE study at 29 centres in China between June 2009 ...

An increased incidence of neoplasia was recently reported in patients with familial dysautonomia. This suggests that, in addition to its role in neuronal development, the IKBKAP gene may also influence DNA repair. Here we report the case of a 28-year-old male with familial dysautonomia who was found to have neoplastic lesions detected post mortem as incidental findings. This case indicates that...

The long term results of midodrine treatment in a patient having debilitating chronic fatigue syndrome (CFS) are reported. Midodrine treatment, directed at the autonomic nervous system, resulted in correction of the dysautonomia followed by improvement of fatigue. This finding is consistent with the hypothesis that dysautonomia plays a major part in the pathophysiology of CFS and that therapies...

Feline dysautonomia is a devastating disease characterized by neuronal degeneration in autonomic ganglia that results in clinical signs related to dysfunction of the sympathetic and parasympathetic nervous systems. The cause is unknown and this disease has a poor prognosis and no definitive treatment. Most reports have been described in few countries around the world, but the prevalence may be ...

Mitral valve prolapse (MVP) is a relatively frequent valvular abnormality. In both children and adults with MVP, an increased incidence of ventricular arrhythmias has been reported. QT dispersion, defined as the difference in duration between the longest QT interval and the shortest one, for a given set of electrocardiographic leads has been proposed as a sign of regional difference in card...

Abstract Funding Acknowledgements Type of funding sources: None. Background In MVP, MAD has been associated with myocardial replacement fibrosis and arrhythmia, but the importance interstitial remains unknown. We aimed to evaluate relationship between mitral annular disjunction (MAD) severity at left ventricular (LV) base in patients valve prolapse (MVP), assess association occurrence arrhythmi...