The experimental induction of leukemias of two sorts by two powerful chemical carcinogens was investigated in rats of a single strain. In Sprague-Dawley rats a series of intravenous injections of N-nitroso-N-methylurea selectively elicited myelogenous leukemia in high yields, whereas erythroleukemia was not evoked. Conversely, a set of intravenous injections of 7,8,12-trimethylbenz[a]anthracene...

The retinoblastoma (RB) protein levels in blast-enriched mononuclear fractions from the peripheral blood of 33 newly diagnosed patients with acute myelogenous leukemia were studied. Ten patients who had previously been treated were also analyzed, nine of whom had achieved prior complete remission. Low RB protein expression was found in 13 of 43 (30%) of the acute myelogenous leukemia patients a...

By THOMAS J. LYNCH AND WILLIAM C. MOLONEY D URING STUDIES on the induction of myelogenous leukemia in the rat, serum B12 afl(I folate activities were investigated. In man it is well known tiiat serum B1 activity is greatly elevated in chronic myelogenous leukemia ( CML ) . Less is known concerning serum folate activity hut from iiiitial reports and in our own experience, serum folate levels are...

DNA-based cytophotometry was used to analyze metaphase chromosomes in four patients with chronic myelogenous leukemia. In three of these patients, both Philadelphia chromosome (Ph1)-positive and Ph1-negative cells were measured. On the basis of these three patients, the characteristic 9q+/22q- translocation of chronic myelogenous leukemia involves the net transfer of 0.325% of the autosomal gen...

T HE ASSOCIATION of a variety of chromosome abnormalities with human leukemias has been well established. The discovery of the Philadelphia chromosome is of particular significance because it is the first instance in which there is an association of a specific chromosome abnormality with a particular type of leukemia. The Philadelphia ( Ph1 ) chromosome is present in the marrow of most patients...

AND LILLIAN GLAZER S CASES of lymphatic and 2 of myelogenous leukemia developed in a group of random bred Wistar rats in which methylcholanthrene was itsstilled into the stomach.5 Attempts were made to transfer each type of leakemia to 30 to 40 clay old rats of our colony with only indifferent success in lymphatic leukemia and complete failure to achieve any transfers its myelogenous leukemia. ...

Therapy-related myelodysplastic syndromes and acute myelogenous leukemia comprise a poor-risk subset of myelodysplastic syndromes and acute myelogenous leukemia. Large-scale mutation profiling efforts in de novo myelodysplastic syndromes have identified mutations that correlate with clinical features, but such mutations have not been investigated in therapy-related myelodysplastic syndromes and...

Acute myelogenous leukemia (AML) develops as the consequence of a series of genetic changes in a hematopoietic precursor cell. Specific cytogenetic abnormalities have been identified by karyotype analysis in AML. One of the rare chromosomal abnormalities is a dicentric chromosome, which is defined as an aberrant chromosome having two centromeres. In the literature, a limited number of cases hav...