Myelofibrosis (MF) is a rare disorder that classified as one of the myeloproliferative disorders. It BCR-ABL1- negative neoplasm characterized by abnormal proliferation hemopoietic stem cells within bone marrow, which leads to overproduction fibrous tissue. Our patient young girl 17 year old presented with lump in left upper abdomen, shortness breath & generalized swelling. The diagnosis wa...

The calreticulin gene has nine exons and most of the frequent mutations screened observed in 9th exon myeloproliferative neoplasm patients, especially essential thrombocythemia primary myelofibrosis. In current study, an uncommon mutation was a 51 y old man with polycythemia vera phenotype. Somatic novel homozygous affect 9 gene. These recent genetic variations were not reported previous studie...

Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of Philadelphia chromosome and BCR-ABL fusion oncogene. CML one illnesses that may be treated using Tyrosine Kinase Inhibitors (TKIs), type targeted therapy. Since TKIs are standard therapy, long-term survival has improved compared to chemotherapy interferon-alpha. For first-line treatment for CML, the...

Myeloproliferative neoplasm-unclassifiable (MPN-U) presents an MPN-type phenotype that fails to meet diagnostic criteria for other MPN variants. Variability in the clinicopathological phenotypes many challenges. Amongst a registry cohort of 1512 patients with MPN, 82 MPN-U were included, median (range) age 49·7 (13–79) years. Albeit heterogeneous, common presentation features included raised la...