In a recent issue of Critical Care, Dr King and colleagues [1] described the role of cardiac troponin as a prognosticator in critically ill medical patients. They concluded that elevated troponin levels measured on admission are associated with an increased mortality rate. Our experience [2] supports that reported by King and coworkers. Our retrospective case note study, conducted in 180 consec...

background: information regarding serum biochemicalprofile can reflect cardiovascular performance in animals.although studies have evaluated the inter-relationship amongcardiovascular biomarkers in animals and human beings, thereare no reports of such a probable relationship in camelids.objectives: the aim of the present study was to provide dataon the correlations among cardiovascular biomarke...

RATIONALE Patients with chronic obstructive pulmonary disease (COPD) have evidence of systemic inflammation that may be implicated in the development of comorbidities. OBJECTIVES To test the hypothesis that elevated levels of three inflammatory biomarkers are associated with increased risk of comorbidities in COPD. METHODS We examined 8,656 patients with COPD from two large Danish populatio...

AIMS The extent to which hemostatic and inflammatory biomarkers are related to angina pectoris as compared with myocardial infarction (MI) remains uncertain. We examined the relationship between a wide range of inflammatory and hemostatic biomarkers, including markers of activated coagulation, fibrinolysis and endothelial dysfunction and viscosity, with incident myocardial infarction (MI) or co...

Introduction: The 2013 American College of Cardiology/ American Heart Association postulated four blood biomarkers for riskstratification and management of heart failure (HF). We proposed a severity index score to assess myocardial injury by integrating the four biomarkers (Troponin I or T, B-type natriuretic peptide or N-terminal BNP, galectin-3, and ST2) and an inclusive score for the therape...

BACKGROUND Atherosclerosis is an inflammatory condition and increased blood levels of inflammatory biomarkers have been observed in acute coronary syndromes. In addition, high expression of inflammatory markers is associated with worse prognosis of coronary artery disease. The presence and extent of inducible ischemia in patients with stable angina has previously been shown to have strong progn...

BACKGROUND Galectin-3 is a biomarker associated with inflammation and fibrosis that predicts adverse outcome and relates to biomarkers of extracellular matrix turnover in patients with heart failure, particularly when left ventricular (LV) systolic function is preserved. Whether galectin-3 is related to LV remodeling after acute myocardial infarction is unknown. METHODS AND RESULTS Circulatin...

BACKGROUND WHO has played a leading role in the formulation and promulgation of standard criteria for the diagnosis of coronary heart disease and myocardial infarction since early 1970s. METHODS The revised definition takes into consideration the following: well-resourced settings can use the ESC/ACC/AHA/WHF definition, which has new biomarkers as a compulsory feature; in resource-constrained...

Acute coronary syndromes (ACS), such as unstable angina, acute myocardial infarction, and sudden cardiac death, are commonly associated with the presence of vulnerable plaques in coronary arteries. Rupture or erosion of vulnerable plaques results in the formation of luminal thrombi due to the physical contact between platelets and thrombogenic elements within the atherosclerotic lesions. Consid...

Abstract According to tradition, every year, at the Congress of European Society Cardiology new clinical guidelines, usefull for our daily pratice, are launched. This year a guideline management non-ST-segment elevation myocardial infarction (NSTEMI) was presented. Substantial resources had been invested sustain research efforts in order improve diagnosis and therapeutic tools this disease. In ...