Gillingham, Melanie B., Elizabeth M. Dahly, Hannah V. Carey, Melanee D. Clark, Karen R.. Kritsch, and Denise M. Ney. Differential jejunal and colonic adaptation due to resection and IGF-I in parenterally fed rats. Am J Physiol Gastrointest Liver Physiol 278: G700–G709, 2000.— Patients with severe short-bowel syndrome (SBS) often require long-term total parenteral nutrition (TPN) to maintain the...

HINDRIK MULDER,1,2 SAMUEL GEBRE-MEDHIN,3,4 CHRISTER BETSHOLTZ,4 FRANK SUNDLER,2 AND BO AHRÉN5 1Section for Molecular Signaling, Department of Cell and Molecular Biology, Lund University, SE-221 00 Lund; 2Section for Neuroendocrine Cell Biology, Department of Physiological Sciences, Lund University, SE-221 85 Lund; 3Section for Molecular and Cellular Physiology, Department of Physiological Scien...

Peripheral arterial disease (intermittent claudication) is typically age-dependent and is not uncommon after the age of about 65 years. Exercise training in peripheral arterial disease leads to an increased walking distance and reduced pain, and likely also a slowed progression of the disease process itself. For optimal effect, the exercise should be carried out as walk training, preferably int...

Kreisman, Stuart H., Anthony Manzon, Sharon J. Nessim, José A. Morais, Réjeanne Gougeon, Simon J. Fisher, Mladen Vranic, and Errol B. Marliss. Glucoregulatory responses to intense exercise performed in the postprandial state. Am J Physiol Endocrinol Metab 278: E786–E793, 2000.—A sevento eightfold increment in hepatic glucose production (endogenous Ra) occurs in postabsorptive (PA) intense exerc...

RHONDA C. VANN,1 HANH V. NGUYEN,1 PETER J. REEDS,1 DOUGLAS G. BURRIN,1 MARTA L. FIOROTTO,1 NORMAN C. STEELE,2 DANIEL R. DEAVER,3 AND TERESA A. DAVIS1 1United States Department of Agriculture/Agricultural Research Service Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030; 2United States Department of Agriculture/Agricultural Research...

Forhead, A. J., J. Li, J. C. Saunders, M. J. Dauncey, R. S. Gilmour, and A. L. Fowden. Control of ovine hepatic growth hormone receptor and insulin-like growth factor I by thyroid hormones in utero. Am J Physiol Endocrinol Metab 278: E1166–E1174, 2000.—By use of RNase protection assays, hepatic growth hormone receptor (GHR) and insulinlike growth factor I (IGF-I) mRNA abundances were measured i...

Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic goblet cells is unknown. To address this issue,we havegenerated composite tamoxifen-inducible intestine-specific genetic mouse...

Evans, Jodi F., James K. Yeh, and John F. Aloia. Osteoblast-like cells of the hypophysectomized rat: a model of aberrant osteoblast development. Am J Physiol Endocrinol Metab 278: E832–E838, 2000.—In a previous work, we demonstrated that the osteoprogenitors derived from the marrow stroma of the hypophysectomized (HX) rat demonstrate enhanced proliferative and differentiation capacities when pl...

Haisch, M., N. K. Fukagawa, and D. E. Matthews. Oxidation of glutamine by the splanchnic bed in humans. Am J Physiol Endocrinol Metab 278: E593–E602, 2000.—[1,2C2]glutamine and [ring-H5]phenylalanine were infused for 7 h into five postabsorptive healthy subjects on two occasions. On one occasion, the tracers were infused intravenously for 3.5 h and then by a nasogastric tube for 3.5 h. The orde...

Goldfarb, David S., William S. Sly, Abdul Waheed, and Alan N. Charney. Acid-base effects on electrolyte transport in CA II-deficient mouse colon. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G409–G415, 2000.—To determine the role of carbonic anhydrase (CA) in colonic electrolyte transport, we studied Car-20 mice, mutants deficient in cytosolic CA II. Ion fluxes were measured under short-ci...