background contrast-induced nephropathy (cin) is one of the most important complications of angiography in patients with chronic kidney disease (ckd) or diabetes mellitus. the prevention of cin can decrease therapeutic costs and hospital stays. there is controversy in the literature over the preventive effect of statins on cin. objectives this study was designed to evaluate the preventive effec...

dial revascularization. Eur J Cardiothorac Surg 2004;25:597–604. 7. Zhu J, Yin R, Shao H, Dong G, Luo L, Jing H. N-Acetylcysteine to ameliorate acute renal injury in a rat cardiopulmonary bypass model. J Thorac Cardiovasc Surg 2007; 133:696–703. 8. Tossios P, Bloch W, Huebner A, Raji MR, Dodos F, Klass O, Suedkamp M, Kasper SM, Hellmich M, Mehlhorn U. N-Acetylcysteine prevents reactive oxygen s...

BACKGROUND An elevated blood level of homocysteine is a risk factor for cognitive impairment and dementia. Homocysteine can be lowered by folate and/or vitamin B12 supplementation; antioxidants might also be required for optimal reduction in neurovascular tissue. This report presents clinical and radiological findings from administering the antioxidant N-acetylcysteine together with B vitamins ...

Oxidative stress plays a central role in the pathogenesis of heart failure. We aimed to determine whether the antioxidantN-acetylcysteine can attenuate cardiac fibrosis and remodeling in a mouse model of heart failure. Minipumps were implanted subcutaneously in wild-type mice (n = 20) and mice with cardiomyopathy secondary to cardiac specific overexpression of mammalian sterile 20-like kinase 1...

background: the purpose of our study was to determine the effect of n-acetylcysteine (nac) administered after successful cardiopulmonary resuscitation (cpr) on renal function of the survived patients. methods: in this double-blinded randomized clinical trial, 44 patients who experienced cardiopulmonary arrest and underwent successful cardiopulmonary resuscitation (cpr) were entered into the stu...

OBJECTIVE Reactive oxygen species have been shown to contribute to myocardial stress in patients undergoing cardiac surgery, as demonstrated by myocardial 8-iso-prostaglandin-F(2)alpha and nitrotyrosine formation. We hypothesized that the reactive oxygen species scavenger N-acetylcysteine attenuates reactive oxygen species-mediated myocardial stress in patients undergoing cardiac surgery. MET...